9-Aminoacridine peptide derivatives as versatile reporter systems for use in fluorescence lifetime assays

9-Aminoacridine peptide derivatives as versatile reporter systems for use in fluorescence lifetime assays

A novel long lifetime fluorescence reporter based on 9-aminoacridine was designed, the lifetime of which can be modulated in a defined manner when in proximity to a tryptophan residue enabling fluorescence lifetime based biochemical assays to be configured.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) Vol. 46; no. 37; p. 6929
Main Authors: Maltman, Beatrice A, Dunsmore, Colin J, Couturier, Sarah C M, Tirnaveanu, Adina E, Delbederi, Zoica, McMordie, R Austin S, Naredo, Gregorio, Ramage, Robert, Cotton, Graham
Format: Journal Article
Language:English
Published: England 07-10-2010
Subjects:
Aminacrine - chemistry
Biological Assay - methods
Fluorescence
Molecular Structure
Peptides - chemical synthesis
Peptides - chemistry
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Description
Summary:A novel long lifetime fluorescence reporter based on 9-aminoacridine was designed, the lifetime of which can be modulated in a defined manner when in proximity to a tryptophan residue enabling fluorescence lifetime based biochemical assays to be configured.
ISSN:1364-548X
DOI:10.1039/c0cc01901a