The test-retest reliability and minimal detectable change of the six-minute walk test, timed up and go test, and 30-second chair stand test in people with epilepsy

• Published in: Physiotherapy theory and practice Vol. 40; no. 10; pp. 2298 - 2407
• Main Authors: Aktar, Burcin, Balci, Birgul, Oztura, Ibrahim, Baklan, Baris
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Ltd 01-10-2024
• Subjects: Adult; Agreements; Changes; Clinical medicine; Epilepsy; Epilepsy - diagnosis; Epilepsy - physiopathology; Exercise Test - methods; Female; Humans; Male; Measurement; Middle Aged; Mobility; Muscle strength; Muscle Strength - physiology; Physical therapists; Postural Balance - physiology; Random effects; Reproducibility of Results; Test-Retest reliability; Walk Test; Young Adult; test-retest reliability; seizure disorders; epilepsies; six-minute walk test
• ISSN: 0959-3985; 1532-5040; 1532-5040
• DOI: 10.1080/09593985.2023.2237566

The available evidence suggests that people with epilepsy have reduced cardio-respiratory fitness and muscle strength endurance, and impaired balance and mobility. The 6-minute walk test (6MWT), Timed Up and Go (TUG), and 30-second chair stand test (30CST) are physical performance tests frequently used in clinical practice.
To establish the test-retest reliability and minimal detectable change of the 6MWT, TUG, and 30CST in people with epilepsy.
The study was designed as an observational study. Forty-one people with epilepsy (23 females, 18 males; mean age 34.7 ± 10.4 years) participated. The 6MWT, TUG, and 30CST were tested by a trained physiotherapist during two sessions, which were conducted 7-14 days apart. The test-retest reliability of measures was assessed using the intra-class correlation coefficients (ICC) using two-way random effects and absolute agreement methods. The 95% limits of agreement, standard error of measurement (SEM), and minimal detectable change (MDC₉₅) were calculated.
The 6MWT (ICC = 0.92, SEM = 15.8, MDC₉₅ = 43.8), TUG (ICC = 0.95, SEM = 3.2, MDC₉₅ = 0.5) and 30CST (ICC = 0.92, SEM = 1.0, MDC₉₅ = 2.8) performance measurements demonstrated excellent test-retest reliability. The 95% limits of agreement was calculated, as illustrated in a Bland-Altman plot.
The 6MWT, TUG, and 30CST are reliable for measuring physical performance. The findings of this study can support researchers and clinicians to decide if a change score of a person with epilepsy is likely to be measurement error or true change.