Multicenter study of radiosynoviorthesis. Clinical outcome in osteoarthritis and other disorders with concomitant synovitis in comparison with rheumatoid arthritis

• Published in: Nuclear medicine Vol. 43; no. 2; p. 57
• Main Authors: Rau, H, Lohmann, K, Franke, C, Goretzki, G, Lemb, M A, Müller, J, Panholzer, P J, Stelling, E, Spitz, J
• Format: Journal Article
• Language: English; German
• Published: Germany 01-03-2004
• Subjects: Adult; Aged; Aged, 80 and over; Arthritis, Psoriatic - radiotherapy; Arthritis, Rheumatoid - radiotherapy; Female; Humans; Joint Prosthesis - adverse effects; Male; Middle Aged; Osteoarthritis - radiotherapy; Pain; Quality of Life; Radioisotopes - therapeutic use; Synovitis - physiopathology; Synovitis - radiotherapy; Treatment Outcome
• ISSN: 0029-5566
• DOI: 10.1055/s-0038-1625592

Evaluation of the effectiveness of radiosynoviorthesis (RSO) in osteoarthritis and other disorders with concomitant synovitis versus rheumatoid arthritis by means of a standardized questionnaire.
803 RSO treatments were monitored in 691 patients by standardized questionnaires of 7 centers in 3 countries. Patients were assigned to 3 groups according to their age (20-40, 41-60, 61-80 years). Additionally, the data were analyzed separately for patients with rheumatoid arthritis (group A) and those with osteoarthritis, psoriasis arthritis, pigmental villonodular synovitis or persistent effusions after joint replacement (group B).
Ameliorations of joint pain, swelling/effusion or flexibility were found in 80% of group A and 56% of group B (p >0.01). Quality of life improved in 78% of group A and 59% of group B (p >0.01). The response rate was similar for small- and large-sized joints in group A, but significantly higher for large-sized joints in group B (p >0.01). The positive effects on joint pain, swelling/effusion or flexibility lasted longer in group A (p >0.01). Repeated RSOs were as effective as initial ones. The clinical outcome was neither influenced by age, nor gender, nor transient immobilisation for 48 hours after RSO.
Although slightly more efficient in rheumatoid arthritis, RSO represents an effective treatment option also in osteoarthritis and other disorders with concomitant synovitis.