APOE from patient-derived astrocytic extracellular vesicles alleviates neuromyelitis optica spectrum disorder in a mouse model

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune astrocytopathy of the central nervous system, mediated by antibodies against aquaporin-4 water channel protein (AQP4-Abs), resulting in damage of astrocytes with subsequent demyelination and axonal damage. Extracellular communication th...

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Bibliographic Details

Published in:	Science translational medicine Vol. 16; no. 736; p. eadg5116
Main Authors:	Jiang, Shihe, Li, Xindi, Li, Yan, Chang, Zhilin, Yuan, Meng, Zhang, Ying, Zhu, Huimin, Xiu, Yuwen, Cong, Hengri, Yin, Linlin, Yu, Zhen-Wei, Fan, Junwan, He, Wenyan, Shi, Kaibin, Tian, De-Cai, Zhang, Jing, Verkhratsky, Alexei, Jin, Wei-Na, Shi, Fu-Dong
Format:	Journal Article
Language:	English
Published:	United States 28-02-2024
Subjects:	Animals Apolipoproteins E Aquaporin 4 Astrocytes - metabolism Autoantibodies Humans Mice Neuromyelitis Optica Proteomics
Online Access:	Get more information
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