hephaestus encodes a polypyrimidine tract binding protein that regulates Notch signalling during wing development in Drosophila melanogaster

We describe the role of the Drosophila melanogaster hephaestus gene in wing development. We have identified several hephaestus mutations that map to a gene encoding a predicted RNA-binding protein highly related to human polypyrimidine tract binding protein and Xenopus laevis 60 kDa Vg1 mRNA-binding...

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Bibliographic Details
Published in:	Development (Cambridge) Vol. 129; no. 24; pp. 5553 - 5566
Main Authors:	Dansereau, David A, Lunke, Martine D, Finkielsztein, Ariel, Russell, Michael A, Brook, William J
Format:	Journal Article
Language:	English
Published:	England The Company of Biologists Limited 15-12-2002
Subjects:	Alleles Animals Cloning, Molecular DNA, Complementary - metabolism Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila Proteins - genetics Drosophila Proteins - metabolism Immunohistochemistry Intracellular Signaling Peptides and Proteins Ligands Membrane Proteins - metabolism Models, Biological Models, Genetic Mutagenesis, Site-Directed Mutation Phenotype Polypyrimidine Tract-Binding Protein - genetics Polypyrimidine Tract-Binding Protein - metabolism Protein Binding Receptors, Notch Signal Transduction Wings, Animal - embryology
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