CYP2C8, PTGS-1, 2 gene polymorphisms prevalence associated with sensitivity to non-steroidal anti-inflammatory drugs among North Caucasus ethnic groups

• Published in: Terapevtic̆eskii arhiv Vol. 93; no. 11; pp. 1334 - 1339
• Main Authors: Abdullaev, Sherzod P., Denisenko, Natalia P., Mirzaev, Karin B., Shuev, Gregorii N., Sozaeva, Zhannet A., Kachanova, Anastasia A., Mammaev, Suleiman N., Kasaeva, Elvira A., Gafurov, Danial M., Grishina, Elena A., Sychev, Dmitry A.
• Format: Journal Article
• Language: English; Russian
• Published: "Consilium Medicum" Publishing house 15-11-2021
• Subjects: cyp2c8; ethnics; non-steroidal anti-inflammatory drugs; pharmacogenetics; ptgs-1; ptgs-2
• ISSN: 0040-3660; 2309-5342
• DOI: 10.26442/00403660.2021.11.201220

Aim. Find the prevalence of CYP2C8*3 (rs10509681; rs11572080), PTGS-1 (rs10306135; rs12353214) and PTGS-2 (rs20417) alleles and genotypes in four ethnic groups among Laks, Avars, Dargins and Kumyks.
Materials and methods. The study involved 400 volunteers from four ethnic groups living in Republic of Dagestan: 100 participants from each group. Carriage of polymorphic markers was determined by reverse transcription polymerase chain reaction.
Results. Minor allele frequency of the CYP2C8 (rs10509681) was 5.5% in Avars, 10% in Dargins, Laks and Kumyks 6.5% both; CYP2C8 (rs11572080) was 5.5% in Avars, 9.5% in Dargins, 6.5% in Laks, 8.5% in Kumyks; PTGS-1 (rs10306135) in Avars 10.5%, in Dargins 13.0%, in Laks 9.5% and Kumyks 7.5%; PTGS-1 (rs12353214) in Avars 9.0%, in Dargins 4.5%, in Laks 7.5%, in Kumyks 8.0%; PTGS-2 (rs20417) in Avars 1.0%, in Dargins 2.5%, in Laks 3.5%, in Kumyks 5.0%. There were no significant differences between groups.
Conclusion. The study of CYP2C8 and PTGS-1 and 2 gene polymorphisms is promising for predicting the effectiveness and safety of non-steroidal anti-inflammatory drug therapy, due to the high prevalence of these polymorphisms in ethnic groups in the North Caucasus.