Inhibition of neutral proteases from polymorphonuclear (PMN) neutrophils by salicylazosulfapyridine (SASP)

Inhibition of neutral proteases from polymorphonuclear (PMN) neutrophils by salicylazosulfapyridine (SASP)

Cytochemical methods were used to demonstrate the inhibitory effect of salicylazosulfapyridine (SASP) on the activity of neutral proteases produced by neutrophilic granulocytes (PMN proteases). The SASP metabolites (5-aminosalicylic acid and sulfapyridine), produced by splitting of SASP by bacteria...

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Bibliographic Details
Published in:Histochemistry Vol. 66; no. 1; pp. 43 - 47
Main Author: Klessen, C
Format: Journal Article
Language:English
Published: Germany 1980
Subjects:
Adult
Aminosalicylic Acids - pharmacology
Humans
Neutrophils - drug effects
Neutrophils - enzymology
Protease Inhibitors
Sulfapyridine - pharmacology
Sulfasalazine - pharmacology
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Summary:Cytochemical methods were used to demonstrate the inhibitory effect of salicylazosulfapyridine (SASP) on the activity of neutral proteases produced by neutrophilic granulocytes (PMN proteases). The SASP metabolites (5-aminosalicylic acid and sulfapyridine), produced by splitting of SASP by bacteria in the colon, did not inhibit the activity of PMN proteases. Paradoxically, sulfapyridine intensified PMN protease activity. A similar effect however could not be demonstrated for 5-aminosalicylic acid.
ISSN:0301-5564
1432-119X
DOI:10.1007/BF00493244