The influence of ovariectomy on the sex-dependent effects of the anticholinesterase diisopropyl fluorophosphate

Temperature and water uptake were reduced to a greater degree in ovariectomized female and normal male rats than in sham-operated female rats following an acute administration of 1 mg/kg of the anticholinesterase diisopropyl fluorophosphate (DFP). Ovariectomy also led to a significant reduction in t...

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Bibliographic Details
Published in:	Psychopharmacology Vol. 74; no. 4; pp. 391 - 392
Main Authors:	Overstreet, D H, Russell, R W, Kerni, W, Netherton, R A
Format:	Journal Article
Language:	English
Published:	Germany 01-01-1981
Subjects:	Animals Body Temperature - drug effects Body Weight - drug effects Castration Cholinesterases - blood Drinking - drug effects Female Isoflurophate - pharmacology Male Rats Rats, Inbred Strains Sex Factors
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Summary:	Temperature and water uptake were reduced to a greater degree in ovariectomized female and normal male rats than in sham-operated female rats following an acute administration of 1 mg/kg of the anticholinesterase diisopropyl fluorophosphate (DFP). Ovariectomy also led to a significant reduction in the level of serum cholinesterase activity. These findings add further support for the hypothesis that the sex-dependent effects of DFP are due, at least in part, to sex differences in serum cholinesterase activity.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0033-3158 1432-2072
DOI:	10.1007/BF00432755