Pharmacokinetics of the aldose reductase inhibitor imirestat following topical ocular administration

The pharmacokinetics of imirestat following topical ocular administration were evaluated in a series of studies in rabbits and dogs. Following single topical doses to both albino and pigmented rabbits, imirestat was subject to rapid uptake into the cornea followed by an initial rapid decline and the...

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Bibliographic Details
Published in:	Pharmaceutical research Vol. 7; no. 2; pp. 192 - 198
Main Authors:	BRAZZELL, R. K, WOOLDRIDGE, C. B, HACKETT, R. B, MCCUE, B. A
Format:	Journal Article
Language:	English
Published:	New York, NY Springer 01-02-1990
Subjects:	Administration, Topical Aldehyde Reductase - antagonists & inhibitors Animals Biological and medical sciences Biological Availability Dogs Eye Fluorenes - administration & dosage Fluorenes - pharmacokinetics Hydantoins - administration & dosage Hydantoins - pharmacokinetics Hydrogen-Ion Concentration Medical sciences Pharmacology. Drug treatments Rabbits Sugar Alcohol Dehydrogenases - antagonists & inhibitors Tissue Distribution Multiple dose Eye Aldose reductase Animal Single dose Enzyme inhibitor Bioavailability Pharmacokinetics Intraocular administration
Online Access:	Get full text
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