Synthesis and preliminary biological evaluations of [18F]-1-deoxy-1-fluoro-scyllo-inositol

A novel PET radiotracer, [18F]-1-deoxy-1-fluoro-scyllo-inositol, was synthesized via a one-pot reaction in 16 +/- 3% uncorrected radiochemical yield within 80 minutes; although this compound revealed low brain penetration it shows promise in rodent tumour models for breast cancer imaging.

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Bibliographic Details
Published in:	Chemical communications (Cambridge, England) no. 37; p. 5527
Main Authors:	Vasdev, Neil, Chio, Jason, van Oosten, Erik M, Nitz, Mark, McLaurin, Joanne, Vines, Douglass C, Houle, Sylvain, Reilly, Raymond M, Wilson, Alan A
Format:	Journal Article
Language:	English
Published:	England 01-01-2009
Subjects:	Animals Cell Line, Tumor Fluorine Radioisotopes - chemistry Humans Inositol - analogs & derivatives Inositol - chemical synthesis Inositol - chemistry Male Mice Positron-Emission Tomography Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - chemistry Rats Rats, Sprague-Dawley Stereoisomerism Transplantation, Heterologous
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Description
Summary:	A novel PET radiotracer, [18F]-1-deoxy-1-fluoro-scyllo-inositol, was synthesized via a one-pot reaction in 16 +/- 3% uncorrected radiochemical yield within 80 minutes; although this compound revealed low brain penetration it shows promise in rodent tumour models for breast cancer imaging.
ISSN:	1364-548X
DOI:	10.1039/b913317h