Microwave-assisted synthesis, spectroscopic characterization, and biological evaluation of fused thieno[2,3-d]pyrimidines as potential anti-cancer agents targeting EGFRWT and EGFRT790M

Epidermal growth factor receptor (EGFR) is a transmembrane protein tyrosine kinase that is usually overexpressed in many types of cancers. In the present study, an effort was done in synthesis of new 3,4-diaminothieno[2,3-b] thiophene-2,5-dicarbonitrile derivatives 2–8 , assisted by a microwave devi...

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Bibliographic Details

Published in:	Molecular diversity Vol. 27; no. 2; pp. 901 - 917
Main Authors:	Aboelez, Moustafa O., Kamel, Moumen S., Belal, Amany, El Badry Abdel-Aziz, Ahmed, Abourehab, Mohammed A. S., Abdel-Ghany, H., A. El Hamd, Mohamed, El-Remaily, Mahmoud Abd El Aleem Ali
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01-04-2023 Springer Nature B.V
Subjects:	Biochemistry Biomedical and Life Sciences Cytotoxicity Life Sciences Organic Chemistry Original Article Pharmacy Polymer Sciences Microwave Pyrimidines Anticancer agents EGFR
Online Access:	Get full text
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