Osteoporosis in rheumatoid arthritis: effect of disease activity

In addition to juxtaarticular osteoporosis, which appears to reflect predominantly local disease mechanisms, more generalized bone loss can occur in rheumatoid arthritis (RA). The aim of this study was to compare bone mineral density (BMD) of the lumbar spine and proximal femur in RA patients versus...

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Bibliographic Details
Published in:	Clinical rheumatology Vol. 14; no. 4; pp. 429 - 433
Main Authors:	Celiker, R, Gökçe-Kutsal, Y, Cindas, A, Ariyürek, M, Renda, N, Koray, Z, Basgöze, O
Format:	Journal Article
Language:	English
Published:	Germany 01-07-1995
Subjects:	Absorptiometry, Photon Adult Aged Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - physiopathology Bone Density - physiology Female Humans Male Middle Aged Osteocalcin - blood Osteoporosis - etiology Osteoporosis - physiopathology Risk Factors
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Summary:	In addition to juxtaarticular osteoporosis, which appears to reflect predominantly local disease mechanisms, more generalized bone loss can occur in rheumatoid arthritis (RA). The aim of this study was to compare bone mineral density (BMD) of the lumbar spine and proximal femur in RA patients versus controls and evaluate the influence of disease related determinants. Twenty-seven patients with RA and twenty healthy subjects were included in this study. BMD was significantly reduced in RA patients compared with the control group. BMD was correlated with duration of disease, health assessment questionnaire scores, hand grip strength and erythrocyte sedimentation rate. These results support the hypothesis that BMD may be affected by RA related determinants.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0770-3198 1434-9949
DOI:	10.1007/BF02207677