Cystine-glutamate transport interactions in rat renal cortical tubules, brushborder vesicles, and cultured renal tubule cells

Glutamate had no significant effect on the uptake of 0.025 mM cystine by isolated rat renal cortical tubules and brushborder membrane vesicles in contrast to lysine which significantly inhibits cystine transport. Glutamate, however, markedly inhibited cystine uptake by rat renal tubule cells grown i...

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Bibliographic Details
Published in:	Bioscience reports Vol. 6; no. 1; p. 113
Main Authors:	Foreman, J W, McNamara, P D, Bowring, M A, Lee, J, Rea, C, Segal, S
Format:	Journal Article
Language:	English
Published:	England 01-01-1986
Subjects:	Animals Biological Transport Cell Membrane - metabolism Cells, Cultured Culture Techniques Cystine - metabolism Drug Interactions Glutamates - pharmacology Glutamic Acid Kidney Cortex - ultrastructure Kidney Tubules - drug effects Kidney Tubules - metabolism Kidney Tubules - ultrastructure Lysine - pharmacology Male Microvilli - drug effects Microvilli - metabolism Microvilli - ultrastructure Rats Rats, Inbred Strains
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Summary:	Glutamate had no significant effect on the uptake of 0.025 mM cystine by isolated rat renal cortical tubules and brushborder membrane vesicles in contrast to lysine which significantly inhibits cystine transport. Glutamate, however, markedly inhibited cystine uptake by rat renal tubule cells grown in a serum-free, hormonally defined media for 5 days. Lysine also inhibited cystine transport in these cultured renal tubule cells.
ISSN:	0144-8463
DOI:	10.1007/BF01145186