A comparative analysis of virucidal efficiency of biocide agents

• Published in: Voprosy virusologiĭ Vol. 62; no. 1; pp. 41 - 45
• Main Authors: Nosik, Nikolay N, Nosik, D N, Chizhov, A I
• Format: Journal Article
• Language: English
• Published: Russia (Federation) Central Research Institute for Epidemiology 2017
• Subjects: Adenoviridae - drug effects; Adenoviridae - physiology; adenovirus; aldehydes; Aldehydes - chemistry; Aldehydes - pharmacology; amines; Disinfectants - chemistry; Disinfectants - pharmacology; guanidines; Guanidines - chemistry; Guanidines - pharmacology; Hepacivirus - drug effects; Hepacivirus - physiology; hiv; HIV - drug effects; HIV - physiology; Influenza A virus - drug effects; Influenza A virus - physiology; influenza virus a; poliovirus; Poliovirus - drug effects; Poliovirus - physiology; quarterly ammonium compounds; Quaternary Ammonium Compounds - chemistry; Quaternary Ammonium Compounds - pharmacology; Structure-Activity Relationship; vhc; virucidal efficiency; Virus Inactivation
• ISSN: 0507-4088; 2411-2097
• DOI: 10.18821/0507-4088-2017-62-1-41-45

The main groups of biocide agents used for inactivation of bacteria and viruses were studied for their virucidal activity against enveloped (HIV, viral hepatitis C, influenza virus A) and non-enveloped viruses (poliovirus, adenovirus). Their efficiency was analyzed. Quarterly ammonium compounds (QAC) themselves are not able to properly inactivate non-enveloped viruses. However, they can be successfully applied in combination with other biocides (guanidines, aldehydes). Effective composition of QAC with amines and guanidines provided inactivation of viruses (4.0 lgTCID50) in concentrations of 0.166-0.280% for non-enveloped viruses and 0.080-00.185% for enveloped viruses. The combination of QAC with aldehydes is especially effective (0.04-0.64% for non-enveloped viruses). The virucidal efficiency does not directly depend on the QAC concentration in the chemical disinfectants.