Thiol/disulphide homeostasis in celiac disease

AIM To determine dynamic thiol/disulphide homeostasis in celiac disease and to examine the associate with celiac autoantibodies and gluten-free diet.METHODS Seventy three patients with celiac disease and 73 healthy volunteers were enrolled in the study. In both groups, thiol/disulphide homeostasis w...

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Bibliographic Details
Published in:	World journal of gastrointestinal pharmacology and therapeutics Vol. 8; no. 2; pp. 120 - 126
Main Authors:	Kaplan, Mustafa, Ates, Ihsan, Yuksel, Mahmut, Ozderin Ozin, Yasemin, Alisik, Murat, Erel, Ozcan, Kayacetin, Ertugrul
Format:	Journal Article
Language:	English
Published:	United States Baishideng Publishing Group Inc 06-05-2017
Subjects:	Case Control Study Gluten-free diet Oxidative stress Anti-gliadin antibodies Thiol oxidation Anti-tissue transglutaminase antibody
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Summary:	AIM To determine dynamic thiol/disulphide homeostasis in celiac disease and to examine the associate with celiac autoantibodies and gluten-free diet.METHODS Seventy three patients with celiac disease and 73 healthy volunteers were enrolled in the study. In both groups, thiol/disulphide homeostasis was examined with a new colorimetric method recently developed by Erel and Neselioglu. RESULTS In patients with celiac disease, native thiol(P = 0.027) and total thiol(P = 0.031) levels were lower, while disulphide(P < 0.001) level, disulphide/native thiol(P < 0.001) and disulphide/total thiol(P < 0.001) ratios were higher compared to the control group. In patients who do not comply with a gluten-free diet, disulphide/native thiol ratio was found higher compared to the patients who comply with the diet(P < 0.001). In patients withany autoantibody-positive, disulphide/native thiol ratio was observed higher compared to the patients with autoantibody-negative(P < 0.05). It is found that there is a negative correlation between celiac autoantibodies, and native thiol, total thiol levels and native thiol/total thiol ratio, while a positive correlation is observed between disulphide, disulphide/native thiol and disulphide/total thiol levels.CONCLUSION This study is first in the literature which found that the patients with celiac disease the dynamic thiol/disulphide balance shifts through disulphide form compared to the control group.
Bibliography:	Mustafa Kaplan;Ihsan Ates;Mahmut Yuksel;Yasemin Ozderin Ozin;Murat Alisik;Ozcan Erel;Ertugrul Kayacetin;Department of Gastroenterology, Turkey Yuksek Ihtisas Training and Research Hospital;Department of Internal Medicine,Ankara Numune Training and Research Hospital;Department of Biochemistry,Y?ld?r?m Beyaz?t University Medical Faculty ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Telephone: +90-312-5084675 Fax: +90-312-3569003 Correspondence to: Ihsan Ates, MD, Department of Internal Medicine, Ankara Numune Training and Research Hospital, 06500 Ankara, Turkey. dr.ihsanates@hotmail.com Author contributions: Kaplan M and Ates I contributed equally to this work; Kaplan M, Ates I and Yuksel M collected and analyzed the data, and drafted the manuscript; Alisik M and Erel O provided analytical oversight; Ozderin Ozin Y and Kayacetin E designed and supervised the study; Kaplan M, Ates I, Alisik M and Erel O revised the manuscript for important intellectual content; Ozderin Ozin Y and Kaycetin E offered the technical or material support; Kaplan M and Ates I provided administrative support; all authors have read and approved the final version to be published.
ISSN:	2150-5349 2150-5349
DOI:	10.4292/wjgpt.v8.i2.120