Is the mouse nose a miniature version of a rat nose? A computational comparative study

• Published in: Computer methods and programs in biomedicine Vol. 254; p. 108282
• Main Authors: Wu, Zhenxing, Jiang, Jianbo, Lischka, Fritz W., Zhao, Kai
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01-09-2024
• Subjects: Animals; Computational fluid dynamics; Computer Simulation; Gas chromatography; Hydrodynamics; Imaging, Three-Dimensional; Mice; Mice, Inbred C57BL; Micro-CT; Models, Anatomic; Mouse olfactory; Nasal cavity; Nasal Cavity - anatomy & histology; Nasal Cavity - diagnostic imaging; Nasal Cavity - physiology; Nose - anatomy & histology; Nose - physiology; Odorant transport; Odorants; Rats; X-Ray Microtomography; Micro-CT; Odorant transport; Gas chromatography; Nasal cavity; Computational fluid dynamics; Mouse olfactory
• ISSN: 0169-2607; 1872-7565; 1872-7565
• DOI: 10.1016/j.cmpb.2024.108282

•A mouse nasal CFD model provided more detailed information than previously published.•Significant similarity in nasal airflow patterns was observed between mouse and rat.•Moderate differences in ethmoid turbinate complexity and GC efficiency.
Although the mouse is a widely used animal model in biomedical research, there are few published studies on its nasal aerodynamics, potentially due to its small size. It is not appropriate to assume that mice and rats' nasal structure and airflow characteristics are the same because the ratio of nasal surface area to nasal volume and body weight is much higher in a mouse than in a rat. The aim of this work is to use anatomically accurate image-based computational fluid dynamic modeling to quantitatively reveal the characteristics of mouse nasal airflow and mass transport that haven't been detailed before and find key differences to that of rat nose, which will deepen our understanding of the mouse's physiological functions.
We created an anatomically accurate 3D computational nasal model of a B6 mouse using postmortem high-resolution micro-CT scans and simulated the airflow distribution and odor transport patterns under restful breathing conditions. The deposition pattern of airborne particles was also simulated and validated against experimental data. In addition, we calculated the gas chromatograph efficiency of odor transport in the mouse employing the theoretical plate concept and compared it with previous studies involving cat and rat models.
Similar to the published rat model, respiratory and olfactory flow regimes are clearly separated in the mouse nasal cavity. A high-speed dorsal medial (DM) stream was observed, which enhances the delivery speed and efficiency of odor to the ethmoid (olfactory) recess (ER). The DM stream split into axial and secondary paths in the ER. However, the secondary flow in the mouse is less extensive than in the rat. The gas chromatograph efficiency calculations suggest that the rat may possess a moderately higher odorant transport efficiency than that of the mouse due to its more complex ethmoid recess structure and extensive secondary flow. However, the mouse's nasal structure seems to adapt better to varying airflow velocity.
Due to the inherent structural disparities, the rat and mouse models exhibit moderate differences in airflow and mass transport patterns, potentially impacting their olfaction and other behavioral habits.