The choroid plexus synergizes with immune cells during neuroinflammation

The choroid plexus (ChP) is a vital brain barrier and source of cerebrospinal fluid (CSF). Here, we use longitudinal two-photon imaging in awake mice and single-cell transcriptomics to elucidate the mechanisms of ChP regulation of brain inflammation. We used intracerebroventricular injections of lip...

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Bibliographic Details
Published in:	Cell Vol. 187; no. 18; p. 4946
Main Authors:	Xu, Huixin, Lotfy, Peter, Gelb, Sivan, Pragana, Aja, Hehnly, Christine, Byer, Lillian I J, Shipley, Frederick B, Zawadzki, Miriam E, Cui, Jin, Deng, Liwen, Taylor, Milo, Webb, Mya, Lidov, Hart G W, Andermann, Mark L, Chiu, Isaac M, Ordovas-Montanes, Jose, Lehtinen, Maria K
Format:	Journal Article
Language:	English
Published:	United States 05-09-2024
Subjects:	Animals Blood-Brain Barrier - metabolism Choroid Plexus - metabolism Epithelial Cells - metabolism Female Lipopolysaccharides Macrophages - immunology Macrophages - metabolism Male Mice Mice, Inbred C57BL Monocytes - metabolism Neuroinflammatory Diseases - metabolism Neutrophils - immunology Neutrophils - metabolism Tight Junctions - metabolism epiplexus macrophages adhesion molecules colony-stimulating factor 1 neuroinflammation immune recruitment epithelial cells blood-CSF barrier bacterial infection choroid plexus
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