Carboxamide-pyridine N-oxide heterosynthon for crystal engineering and pharmaceutical cocrystals

Carboxamide-pyridine N-oxide heterosynthon for crystal engineering and pharmaceutical cocrystals

The novel carboxamide-pyridine N-oxide synthon, sustained via N-H...O- hydrogen bonding and C-H...O interaction, is shown to assemble isonicotinamide N-oxide in a triple helix architecture and the same heterosynthon is exploited to synthesize cocrystals of barbiturate drugs with 4,4'-bipyridine...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) no. 13; p. 1369
Main Authors: Reddy, L Sreenivas, Babu, N Jagadeesh, Nangia, Ashwini
Format: Journal Article
Language:English
Published: England 01-01-2006
Subjects:
Amides - chemistry
Crystallization
Drug Design
Models, Molecular
Molecular Conformation
Pyridines - chemistry
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Summary:The novel carboxamide-pyridine N-oxide synthon, sustained via N-H...O- hydrogen bonding and C-H...O interaction, is shown to assemble isonicotinamide N-oxide in a triple helix architecture and the same heterosynthon is exploited to synthesize cocrystals of barbiturate drugs with 4,4'-bipyridine N,N'-dioxide.
ISSN:1359-7345
DOI:10.1039/b515510j