Telocyte Behaviour During Inflammation, Repair and Tumour Stroma Formation

• Published in: Advances in experimental medicine and biology Vol. 913; p. 177
• Main Authors: Díaz-Flores, L, Gutiérrez, R, González-Gómez, M, Díaz-Flores, Jr, L, Valladares, F, Rancel, N, Sáez, F J, Madrid, J F
• Format: Journal Article
• Language: English
• Published: United States 01-01-2016
• Subjects: Animals; Antigens, CD34 - genetics; Antigens, CD34 - metabolism; Biomarkers - metabolism; Cancer-Associated Fibroblasts - metabolism; Cancer-Associated Fibroblasts - pathology; Cell Differentiation; Cell Proliferation; Gene Expression; Humans; Inflammation; Macrophages - metabolism; Macrophages - pathology; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Stem Cells - cytology; Stem Cells - metabolism; Telocytes - cytology; Telocytes - metabolism; Wound Healing; Wounds, Penetrating - genetics; Wounds, Penetrating - metabolism; Wounds, Penetrating - pathology
• ISSN: 0065-2598
• DOI: 10.1007/978-981-10-1061-3_12

In this chapter, we outline the role of human CD34+ stromal cells/telocytes (CD34+ SC/TCs) as progenitor cells during repair. The in vivo activation phenomena of CD34+ SC/TCs in this process include increased size; separation from the neighbouring structures (mainly of the vascular walls); association with inflammatory cells, predominantly macrophages; development of the organelles of synthesis (rough endoplasmic reticulum and Golgi apparatus); cell proliferation with presence of mitosis and high proliferative index (transit-amplifying cells); and fibroblastic and myofibroblastic differentiation. A procedure to study these tissue-resident cells, comparison of their behaviour in vivo and in vitro and different behaviour depending on location, time, type of injury (including tumour stroma) and greater or lesser proximity to the injury are also considered.