On the presence of autoreceptors on dopamine neurons in different brain regions

• Published in: Journal of Neural Transmission Vol. 57; no. 3; pp. 129 - 137
• Main Authors: ANDEN, N.-E, GRABOWSKA-ANDEN, M, LILJENBERG, B
• Format: Journal Article
• Language: English
• Published: Wien Springer 01-09-1983; New York, NY
• Subjects: Adrenergic alpha-Agonists - pharmacology; Animals; Azepines - pharmacology; Biological and medical sciences; Brain - drug effects; Brain - metabolism; Central nervous system; Central neurotransmission. Neuromudulation. Pathways and receptors; Dopamine - metabolism; Fundamental and applied biological sciences. Psychology; Male; Methyltyrosines - pharmacology; Neurons - drug effects; Neurons - metabolism; Norepinephrine - metabolism; Rats; Rats, Inbred Strains; Receptors, Dopamine - drug effects; Receptors, Dopamine - metabolism; Vertebrates: nervous system and sense organs; Agonist; Cerebral cortex; Rat; Rodentia; Central nervous system; Autoreceptor; Brain (Vertebrata); Midbrain; Basal ganglion; Dopaminergic receptor; Nucleus accumbens; Vertebrata; Mammalia; Olfactory tubercle; Nervous receptor; Rhinencephalon
• ISSN: 0300-9564; 1435-1463
• DOI: 10.1007/BF01245113

The alpha-methyltyrosine-induced disappearance of dopamine was inhibited by the selective dopamine autoreceptor agonist B-HT 920 in the corpus striatum, the nucleus accumbens, the olfactory tubercle, the limbic cortex, and the rostral part of the cerebral cortex of the rat. These inhibitory actions of B-HT 920 were almost completely reversed by the dopamine receptor antagonist haloperidol, indicating that they were caused by a stimulation of dopamine autoreceptors. In the caudal cortex and the cerebellum, the effects of B-HT 920 and haloperidol were less clear, perhaps due to a low concentration of dopamine and to the occurrence of this dopamine in both dopamine and noradrenaline neurons. In the hypothalamus, B-HT 920 and haloperidol did not change the alpha-methyltyrosine-induced disappearance of dopamine in agreement with previous findings that the tubero-infundibular dopamine neurons are not regulated via dopamine receptors.