Antioxidant status of rats receiving lycopene in different doses

Oral treatment with lycopene (per os) in doses of 10 or 50 mg/kg for 2 weeks led to accumulation of lycopene in the liver, liver microsomes, and blood plasma, increased total plasma antioxidant activity, inhibited LPO in the liver, and decreased solubilization of lysosomal enzymes. Lycopene had no e...

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Bibliographic Details
Published in:	Bulletin of experimental biology and medicine Vol. 135; no. 4; pp. 353 - 357
Main Authors:	Kravchenko, L V, Morozov, S V, Beketova, N A, Deryagina, V P, Avren'eva, L I, Tutel'yan, V A
Format:	Journal Article
Language:	English
Published:	United States Springer Nature B.V 01-04-2003
Subjects:	Animals Antioxidants - administration & dosage Antioxidants - metabolism Carotenoids - administration & dosage Carotenoids - metabolism Humans Lipid Peroxidation Liver - cytology Liver - metabolism Lycopene Lysosomes - enzymology Male Microsomes, Liver - metabolism Rats Rats, Wistar Vitamin E - metabolism
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Summary:	Oral treatment with lycopene (per os) in doses of 10 or 50 mg/kg for 2 weeks led to accumulation of lycopene in the liver, liver microsomes, and blood plasma, increased total plasma antioxidant activity, inhibited LPO in the liver, and decreased solubilization of lysosomal enzymes. Lycopene had no effect on ex vivo resistance of liver microsomes to LPO and activities of antioxidant enzymes in the liver.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-4888 1573-8221
DOI:	10.1023/A:1024608730471