Statin downregulation of miR-652-3p protects endothelium from dyslipidemia by promoting ISL1 expression

Aberrant endothelial function is a major contributing factor in cardiovascular disease. Dyslipidemia leads to decreased nitric oxide (NO) bioavailability, an early sign of endothelial failure. Low insulin gene enhancer protein (ISL1) levels decrease healthy NO bioavailability. We hypothesized that t...

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Bibliographic Details
Published in:	Metabolism, clinical and experimental Vol. 107; p. 154226
Main Authors:	Liang, Liwen, Su, Wenhua, Zhou, Liang, Cao, Yu, Zhou, Xiuli, Liu, Shiqi, Zhao, Yan, Ding, Xiaoxue, Wang, Qian, Zhang, Hong
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-06-2020
Subjects:	Dyslipidemia eNOS ISL1 miR-652 Statin VEGF NO eNOS miRNAs ACh HFD Dyslipidemia HMGCR MDA Scr-miR/shRNA-scr SD EDR CCND2 ECs SNP ANOVA OE HUVEC VEGF 3′-UTR HAECs SOD moxLDL ox-LDL Statin ISL1 CVD GEO miR-652 RD shRNA-ISL1 PE ROS FISH Wt LNA SEMs
Online Access:	Get full text
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