PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes

Type 1 diabetes (T1D) results from autoimmune destruction of β-cells in the pancreas. Protein tyrosine phosphatases (PTPs) are candidate genes for T1D and play a key role in autoimmune disease development and β-cell dysfunction. Here, we assessed the global protein and individual PTP profiles in the...

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Bibliographic Details
Published in:	Diabetes (New York, N.Y.) Vol. 71; no. 4; pp. 653 - 668
Main Authors:	Elvira, Bernat, Vandenbempt, Valerie, Bauzá-Martinez, Julia, Crutzen, Raphaël, Negueruela, Javier, Ibrahim, Hazem, Winder, Matthew L, Brahma, Manoja K, Vekeriotaite, Beata, Martens, Pieter-Jan, Singh, Sumeet Pal, Rossello, Fernando, Lybaert, Pascale, Otonkoski, Timo, Gysemans, Conny, Wu, Wei, Gurzov, Esteban N
Format:	Journal Article
Language:	English
Published:	United States American Diabetes Association 01-04-2022
Subjects:	Age Animals Apoptosis - genetics Autoimmune diseases Autoimmunity Beta cells Calcium CD3 antigen Cell death Cellular stress response Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - metabolism Endoplasmic reticulum Endoplasmic Reticulum Stress - physiology Humans Hyperglycemia Insulin-Secreting Cells - metabolism Interferon Interferon-gamma - pharmacology Interleukin 1 Interleukin 1 receptor antagonist Mice Mice, Inbred NOD Monoclonal antibodies Pancreas Protein folding Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism Proteins PTPN2 protein Stem cells Tyrosine
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