Sustained Phosphorylation of Cytosolic Phospholipase A2 Accompanies Cycloheximide- and Adenovirus-Induced Susceptibility to TNF

In this report we examine the phosphorylation state of cytosolic phospholipase A2 (cPLA2) in C3HA fibroblasts that have been treated with TNF, cycloheximide (CHI), or a combination of both compounds. Our experiments show that TNF and CHI, when used independently, caused the rapid phosphorylation of...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 161; no. 3; pp. 1525 - 1532
Main Authors:	O'Brien, Jennifer B, Piddington, Debra L, Voelkel-Johnson, Christina, Richards, Debra J, Hadley, Leslie A, Laster, Scott M
Format:	Journal Article
Language:	English
Published:	United States Am Assoc Immnol 01-08-1998
Subjects:	3T3 Cells Adenoviridae - immunology Adenoviridae Infections - enzymology Adenoviridae Infections - immunology Animals Calcium - physiology Calcium-Calmodulin-Dependent Protein Kinases - drug effects Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell Line Cycloheximide - pharmacology Cytosol - enzymology Enzyme Activation - immunology Fibroblasts - drug effects Fibroblasts - enzymology Fibroblasts - immunology Immunity, Innate Immunophenotyping Mice Mice, Inbred C3H Phospholipases A - metabolism Phospholipases A2 Phosphoric Monoester Hydrolases - antagonists & inhibitors Phosphorylation - drug effects Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - pharmacology
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