The LCLAT1/LYCAT acyltransferase is required for EGF-mediated phosphatidylinositol-3,4,5-trisphosphate generation and Akt signaling

Receptor tyrosine kinases such as EGF receptor (EGFR) stimulate phosphoinositide 3 kinases to convert phosphatidylinositol-4,5-bisphosophate [PtdIns(4,5)P ] into phosphatidylinositol-3,4,5-trisphosphate [PtdIns(3,4,5)P ]. PtdIns(3,4,5)P then remodels actin and gene expression, and boosts cell surviv...

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Bibliographic Details

Published in:	Molecular biology of the cell Vol. 35; no. 9; p. ar118
Main Authors:	Chan, Victoria, Camardi, Cristina, Zhang, Kai, Orofiamma, Laura A, Anderson, Karen E, Hoque, Jafarul, Bone, Leslie N, Awadeh, Yasmin, Lee, Daniel K C, Fu, Norman J, Chow, Jonathan T S, Salmena, Leonardo, Stephens, Len R, Hawkins, Phillip T, Antonescu, Costin N, Botelho, Roberto J
Format:	Journal Article
Language:	English
Published:	United States The American Society for Cell Biology 01-09-2024
Subjects:	Acyltransferases - metabolism Cell Line, Tumor Cell Proliferation Epidermal Growth Factor - metabolism Epidermal Growth Factor - pharmacology ErbB Receptors - metabolism Humans Phosphatidylinositol Phosphates - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Signal Transduction
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