Effect of chronic administration of chlorpromazine on electrical parameters of command neurons in edible snail
Electrophysiological experiments showed that chronic administration of neuroleptic chlorpromazine depolarized plasma membrane and decreased the threshold of action potential generation in command neuron of defense behavior of edible snail and motoneurons of pneumostome closure reflex. The effects of...
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| Published in: | Bulletin of experimental biology and medicine Vol. 139; no. 3; pp. 272 - 274 |
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Springer Nature B.V
01-03-2005
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| Abstract | Electrophysiological experiments showed that chronic administration of neuroleptic chlorpromazine depolarized plasma membrane and decreased the threshold of action potential generation in command neuron of defense behavior of edible snail and motoneurons of pneumostome closure reflex. The effects of chlorpromazine on electrical parameters of the identified neurons can be explained by its serotonin-depleting action. |
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| AbstractList | Electrophysiological experiments showed that chronic administration of neuroleptic chlorpromazine depolarized plasma membrane and decreased the threshold of action potential generation in command neuron of defense behavior of edible snail and motoneurons of pneumostome closure reflex. The effects of chlorpromazine on electrical parameters of the identified neurons can be explained by its serotonin-depleting action. |
| Author | Gainutdinova, T Kh Meshchaninova, A V Andrianov, V V Silant'eva, D I Gainutdinov, Kh L |
| Author_xml | – sequence: 1 givenname: T Kh surname: Gainutdinova fullname: Gainutdinova, T Kh email: gainutdinov@mail.knc.ru organization: Kazan Physicotechnical Institute, Kazan Research Center, Russian Academy of Sciences. gainutdinov@mail.knc.ru – sequence: 2 givenname: A V surname: Meshchaninova fullname: Meshchaninova, A V – sequence: 3 givenname: V V surname: Andrianov fullname: Andrianov, V V – sequence: 4 givenname: D I surname: Silant'eva fullname: Silant'eva, D I – sequence: 5 givenname: Kh L surname: Gainutdinov fullname: Gainutdinov, Kh L |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16027827$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1002/neu.480170507 10.1242/jeb.204.9.1625 10.1007/BF02150226 10.1016/0166-2236(83)90229-1 10.1016/S0306-3623(96)00530-7 10.1017/S0031182000077878 |
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| DOI | 10.1007/s10517-005-0268-4 |
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| References | I. Creese (268_CR10) 1983; 17 268_CR5 M. F. Mineva (268_CR6) 1987; 15 R. P. Croll (268_CR11) 1997; 29 P. M. Balaban (268_CR2) 1986; 18 268_CR1 G. A. Pavlova (268_CR13) 2001; 204 D. Gadotti (268_CR12) 1986; 17 Kh. L. Gainutdinov (268_CR3) 1999; 49 V. E. D’yakonova (268_CR4) 2001; 376 M. W. Baker (268_CR9) 1995; 46 K. S. Raevskii (268_CR8) 1996; 27 D. A. Sakharov (268_CR14) 1996; 16 G. A. Pavlova (268_CR7) 1996; 32 R. J. Walker (268_CR15) 1996; 113 |
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| SubjectTerms | Action Potentials - drug effects Animals Antipsychotic Agents - pharmacology Chlorpromazine - pharmacology Electrophysiology Helix (Snails) - physiology Microelectrodes Neurons - drug effects Neurons - physiology |
| Title | Effect of chronic administration of chlorpromazine on electrical parameters of command neurons in edible snail |
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