Understanding the Results of a Randomized Trial of Screening Colonoscopy
For more than two decades, colonoscopy has been recommended as one of several available options for colorectal cancer screening, and it has been the predominant form of screening for colorectal cancer used in the United States. However, the best evidence to support its use has been limited to data f...
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| Published in: | The New England journal of medicine Vol. 387; no. 17; pp. 1609 - 1611 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
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Massachusetts Medical Society
27-10-2022
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| Abstract | For more than two decades, colonoscopy has been recommended as one of several available options for colorectal cancer screening, and it has been the predominant form of screening for colorectal cancer used in the United States. However, the best evidence to support its use has been limited to data from cohort studies, which have estimated that this type of screening has been associated with a 40 to 69% decrease in the incidence of colorectal cancer and a 29 to 88% decrease in the risk of death from this disease.
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Unlike randomized, controlled trials, which have provided support for fecal occult . . . |
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| AbstractList | For more than two decades, colonoscopy has been recommended as one of several available options for colorectal cancer screening, and it has been the predominant form of screening for colorectal cancer used in the United States. However, the best evidence to support its use has been limited to data from cohort studies, which have estimated that this type of screening has been associated with a 40 to 69% decrease in the incidence of colorectal cancer and a 29 to 88% decrease in the risk of death from this disease.1 Unlike randomized, controlled trials, which have provided support for fecal occult . . . For more than two decades, colonoscopy has been recommended as one of several available options for colorectal cancer screening, and it has been the predominant form of screening for colorectal cancer used in the United States. However, the best evidence to support its use has been limited to data from cohort studies, which have estimated that this type of screening has been associated with a 40 to 69% decrease in the incidence of colorectal cancer and a 29 to 88% decrease in the risk of death from this disease. 1 Unlike randomized, controlled trials, which have provided support for fecal occult . . . |
| Author | Robertson, Douglas J. Dominitz, Jason A. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36214591$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1056/NEJMoa2208375 10.1056/NEJMoa1108895 10.1056/NEJMoa1100370 10.1016/j.gie.2014.07.058 10.1016/S2468-1253(21)00473-8 10.1001/jama.2022.6644 10.1001/jamainternmed.2016.0960 10.1038/ajg.2017.286 10.1001/jama.2021.4417 10.7326/M20-6689 10.1136/bmj.g2467 10.1053/j.gastro.2019.06.043 |
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| References | Forsberg, A, Westerberg, M, Metcalfe, C (r10) 2022; 7 Ladabaum, U, Dominitz, JA, Kahi, C, Schoen, RE (r1) 2020; 158 Dominitz, JA, Robertson, DJ, Ahnen, DJ (r12) 2017; 112 Rex, DK, Schoenfeld, PS, Cohen, J (r9) 2015; 81 Zauber, AG, Winawer, SJ, O’Brien, MJ (r5) 2012; 366 Brenner, H, Stock, C, Hoffmeister, M (r4) 2014; 348 Schottinger, JE, Jensen, CD, Ghai, NR (r7) 2022; 327 Lin, JS, Perdue, LA, Henrikson, NB, Bean, SI, Blasi, PR (r2) 2021; 325 Quintero, E, Castells, A, Bujanda, L (r11) 2012; 366 Bretthauer, M, Løberg, M, Wieszczy, P (r3) 2022; 387 Pohl, H, Anderson, JC, Aguilera-Fish, A, Calderwood, AH, Mackenzie, TA, Robertson, DJ (r6) 2021; 174 Bretthauer, M, Kaminski, MF, Løberg, M (r8) 2016; 176 36720147 - N Engl J Med. 2023 Jan 26;388(4):379 36720145 - N Engl J Med. 2023 Jan 26;388(4):378 36214590 - N Engl J Med. 2022 Oct 27;387(17):1547-1556 e_1_3_4_3_2 e_1_3_4_11_2 e_1_3_4_2_2 e_1_3_4_12_2 e_1_3_4_10_2 e_1_3_4_13_2 e_1_3_4_9_2 e_1_3_4_8_2 e_1_3_4_7_2 e_1_3_4_6_2 e_1_3_4_5_2 e_1_3_4_4_2 |
| References_xml | – volume: 81 start-page: 31 year: 2015 end-page: 53 ident: r9 article-title: Quality indicators for colonoscopy. publication-title: Gastrointest Endosc contributor: fullname: Cohen, J – volume: 366 start-page: 697 year: 2012 end-page: 706 ident: r11 article-title: Colonoscopy versus fecal immunochemical testing in colorectal-cancer screening. publication-title: N Engl J Med contributor: fullname: Bujanda, L – volume: 327 start-page: 2114 year: 2022 end-page: 2122 ident: r7 article-title: Association of physician adenoma detection rates with postcolonoscopy colorectal cancer. publication-title: JAMA contributor: fullname: Ghai, NR – volume: 325 start-page: 1978 year: 2021 end-page: 1998 ident: r2 article-title: Screening for colorectal cancer: updated evidence report and systematic review for the US Preventive Services Task Force. publication-title: JAMA contributor: fullname: Blasi, PR – volume: 112 start-page: 1736 year: 2017 end-page: 1746 ident: r12 article-title: Colonoscopy vs. fecal immunochemical test in reducing mortality from colorectal cancer (CONFIRM): rationale for study design. publication-title: Am J Gastroenterol contributor: fullname: Ahnen, DJ – volume: 176 start-page: 894 year: 2016 end-page: 902 ident: r8 article-title: Population-based colonoscopy screening for colorectal cancer: a randomized clinical trial. publication-title: JAMA Intern Med contributor: fullname: Løberg, M – volume: 7 start-page: 513 year: 2022 end-page: 521 ident: r10 article-title: Once-only colonoscopy or two rounds of faecal immunochemical testing 2 years apart for colorectal cancer screening (SCREESCO): preliminary report of a randomised controlled trial. publication-title: Lancet Gastroenterol Hepatol contributor: fullname: Metcalfe, C – volume: 174 start-page: 1377 year: 2021 end-page: 1384 ident: r6 article-title: Recurrence of colorectal neoplastic polyps after incomplete resection. publication-title: Ann Intern Med contributor: fullname: Robertson, DJ – volume: 348 start-page: g2467 year: 2014 end-page: g2467 ident: r4 article-title: Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: systematic review and meta-analysis of randomised controlled trials and observational studies. publication-title: BMJ contributor: fullname: Hoffmeister, M – volume: 366 start-page: 687 year: 2012 end-page: 696 ident: r5 article-title: Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths. publication-title: N Engl J Med contributor: fullname: O’Brien, MJ – volume: 387 start-page: 1547 year: 2022 end-page: 1556 ident: r3 article-title: Effect of colonoscopy screening on risks of colorectal cancer and related death. publication-title: N Engl J Med contributor: fullname: Wieszczy, P – volume: 158 start-page: 418 year: 2020 end-page: 432 ident: r1 article-title: Strategies for colorectal cancer screening. publication-title: Gastroenterology contributor: fullname: Schoen, RE – ident: e_1_3_4_4_2 doi: 10.1056/NEJMoa2208375 – ident: e_1_3_4_12_2 doi: 10.1056/NEJMoa1108895 – ident: e_1_3_4_6_2 doi: 10.1056/NEJMoa1100370 – ident: e_1_3_4_10_2 doi: 10.1016/j.gie.2014.07.058 – ident: e_1_3_4_11_2 doi: 10.1016/S2468-1253(21)00473-8 – ident: e_1_3_4_8_2 doi: 10.1001/jama.2022.6644 – ident: e_1_3_4_9_2 doi: 10.1001/jamainternmed.2016.0960 – ident: e_1_3_4_13_2 doi: 10.1038/ajg.2017.286 – ident: e_1_3_4_3_2 doi: 10.1001/jama.2021.4417 – ident: e_1_3_4_7_2 doi: 10.7326/M20-6689 – ident: e_1_3_4_5_2 doi: 10.1136/bmj.g2467 – ident: e_1_3_4_2_2 doi: 10.1053/j.gastro.2019.06.043 |
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| SubjectTerms | Cancer Cancer screening Clinical Medicine Clinical Medicine General Cohort analysis Colonoscopy Colonoscopy - methods Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - diagnosis Early Detection of Cancer - methods Gastroenterology Gastrointestinal Tract Cancer Hematology Humans Mass Screening - methods Medical screening Oncology Outpatient-Based Clinical Medicine Randomized Controlled Trials as Topic Tumors |
| SubjectTermsDisplay | Clinical Medicine Clinical Medicine General Gastroenterology Gastrointestinal Tract Cancer Hematology/Oncology Outpatient-Based Clinical Medicine |
| Title | Understanding the Results of a Randomized Trial of Screening Colonoscopy |
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