Hypercalcemia and hyperphosphatemia associated with 25-OH vitamin D deficiency in an alcoholic patient with normal renal function

• Published in: Journal of clinical and translational endocrinology case reports Vol. 23; p. 100107
• Main Authors: Asada, Tomohiko, Iwata, Minoru, Matsuzaki, Shigeru, Hamakawa, Hiroshi, Sengan, Satoru, Noguchi, Toshifumi, Daimon, Kazushi, Matsumura, Naoki, Shibasaki, Morikazu, Tsujimoto, Tetsushi, Ooi, Ken, Fukuyama, Hidenao
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-03-2022; Elsevier
• Subjects: 25-OH vitamin D deficiency; Alcoholic liver damage; Alcoholic patient; Excessive renal reabsorption; Hypercalcemia with hyperphosphatemia; Normal renal function; Alcoholic patient; Alcoholic liver damage; Normal renal function; Hypercalcemia with hyperphosphatemia; Excessive renal reabsorption; 25-OH vitamin D deficiency
• ISSN: 2214-6245; 2214-6245
• DOI: 10.1016/j.jecr.2022.100107

We present the case of a 55-year-old female patient with alcohol-related liver damage who presented with hypercalcemia and hyperphosphatemia but also showed severe paradoxical reduction in serum 25-OH vitamin D levels. The serum levels of 1, 25-(OH) 2 vitamin D, parathyroid hormone, and renal function parameters were normal. Therefore, we examined the renal reabsorption of calcium and phosphate and found a mild increase in both. The serum levels of calcium and phosphate might be determined by 1, 25-(OH) 2 vitamin D-mediated excessive renal reabsorption of calcium and phosphate in alcoholics with 25-OH vitamin D deficiency but normal renal function.