Hedgehog signaling in skeletal development
Hedgehog signaling coordinates a variety of patterning processes during early embryonic development. Drosophila hedgehog and its vertebrate orthologs, Sonic hedgehog, Indian hedgehog, and Desert hedgehog, share a generally conserved signal transduction cascade. However, the particular mechanisms by...
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| Published in: | Birth defects research. Part C. Embryo today Vol. 78; no. 3; pp. 267 - 279 |
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| Abstract | Hedgehog signaling coordinates a variety of patterning processes during early embryonic development. Drosophila hedgehog and its vertebrate orthologs, Sonic hedgehog, Indian hedgehog, and Desert hedgehog, share a generally conserved signal transduction cascade. However, the particular mechanisms by which the lipid‐modified molecules specify embryonic tissues differ substantially. Vertebrate skeletal patterning is one of the most intensively studied biological processes. During skeletogenesis, Sonic and Indian hedgehog provide positional information and initiate or maintain cellular differentiation programs regulating the formation of cartilage and bone. They either signal directly to adjacent cells or form tightly regulated gradients that act over long distances to pattern the axial and appendicular skeleton and regulate crucial steps during endochondral ossification. As a consequence, malfunction of the hedgehog signaling network can cause severe skeletal disorders and tumors. Birth Defects Research (Part C) 78:267–279, 2006. © 2006 Wiley‐Liss, Inc. |
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| AbstractList | Abstract
Hedgehog signaling coordinates a variety of patterning processes during early embryonic development.
Drosophila
hedgehog and its vertebrate orthologs, Sonic hedgehog, Indian hedgehog, and Desert hedgehog, share a generally conserved signal transduction cascade. However, the particular mechanisms by which the lipid‐modified molecules specify embryonic tissues differ substantially. Vertebrate skeletal patterning is one of the most intensively studied biological processes. During skeletogenesis, Sonic and Indian hedgehog provide positional information and initiate or maintain cellular differentiation programs regulating the formation of cartilage and bone. They either signal directly to adjacent cells or form tightly regulated gradients that act over long distances to pattern the axial and appendicular skeleton and regulate crucial steps during endochondral ossification. As a consequence, malfunction of the hedgehog signaling network can cause severe skeletal disorders and tumors. Birth Defects Research (Part C) 78:267–279, 2006. © 2006 Wiley‐Liss, Inc. Hedgehog signaling coordinates a variety of patterning processes during early embryonic development. Drosophila hedgehog and its vertebrate orthologs, Sonic hedgehog, Indian hedgehog, and Desert hedgehog, share a generally conserved signal transduction cascade. However, the particular mechanisms by which the lipid-modified molecules specify embryonic tissues differ substantially. Vertebrate skeletal patterning is one of the most intensively studied biological processes. During skeletogenesis, Sonic and Indian hedgehog provide positional information and initiate or maintain cellular differentiation programs regulating the formation of cartilage and bone. They either signal directly to adjacent cells or form tightly regulated gradients that act over long distances to pattern the axial and appendicular skeleton and regulate crucial steps during endochondral ossification. As a consequence, malfunction of the hedgehog signaling network can cause severe skeletal disorders and tumors. Hedgehog signaling coordinates a variety of patterning processes during early embryonic development. Drosophila hedgehog and its vertebrate orthologs, Sonic hedgehog, Indian hedgehog, and Desert hedgehog, share a generally conserved signal transduction cascade. However, the particular mechanisms by which the lipid‐modified molecules specify embryonic tissues differ substantially. Vertebrate skeletal patterning is one of the most intensively studied biological processes. During skeletogenesis, Sonic and Indian hedgehog provide positional information and initiate or maintain cellular differentiation programs regulating the formation of cartilage and bone. They either signal directly to adjacent cells or form tightly regulated gradients that act over long distances to pattern the axial and appendicular skeleton and regulate crucial steps during endochondral ossification. As a consequence, malfunction of the hedgehog signaling network can cause severe skeletal disorders and tumors. Birth Defects Research (Part C) 78:267–279, 2006. © 2006 Wiley‐Liss, Inc. |
| Author | Vortkamp, Andrea Ehlen, Harald W.A. Buelens, Laetitia A. |
| Author_xml | – sequence: 1 givenname: Harald W.A. surname: Ehlen fullname: Ehlen, Harald W.A. organization: University of Duisburg-Essen, Center for Medical Biotechnology, Essen, Germany – sequence: 2 givenname: Laetitia A. surname: Buelens fullname: Buelens, Laetitia A. organization: University of Duisburg-Essen, Center for Medical Biotechnology, Essen, Germany – sequence: 3 givenname: Andrea surname: Vortkamp fullname: Vortkamp, Andrea email: andrea.vortkamp@uni-due.de organization: University of Duisburg-Essen, Center for Medical Biotechnology, Essen, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17061262$$D View this record in MEDLINE/PubMed |
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| Snippet | Hedgehog signaling coordinates a variety of patterning processes during early embryonic development. Drosophila hedgehog and its vertebrate orthologs, Sonic... Abstract Hedgehog signaling coordinates a variety of patterning processes during early embryonic development. Drosophila hedgehog and its vertebrate orthologs,... |
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| SubjectTerms | Animals Bone and Bones - embryology Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Gene Expression Regulation, Developmental Hedgehog Proteins - physiology Osteogenesis Signal Transduction |
| Title | Hedgehog signaling in skeletal development |
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