Life-Threatening Acute Systemic Lupus Erythematosus: Survival After Multiple Extracorporeal Modalities: A Place for the Multipotential Extracorporeal Service

• Published in: ASAIO journal (1992) Vol. 46; no. 1; pp. 146 - 149
• Main Authors: Tandon, M, Reynolds, H Neal, Borg, Ulf, Habashi, Nader M, Cottingham, Christine
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Philadelphia, PA Lippincott Williams & Wilkins, Inc 01-01-2000; Hagerstown, MD Lippincott
• Subjects: Acute Disease; Adult; Biological and medical sciences; Diseases; Female; Health care; Hemodiafiltration; Humans; Lupus Erythematosus, Systemic - therapy; Medical sciences; Oxygenators; Plasma Exchange; Respiratory therapy; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Human; Immunopathology; Connective tissue disease; Skin disease; Acute; Multiple organ failure; Autoimmune disease; Respiratory support; Plasmapheresis; Case study; Extracorporeal bypass; Systemic disease; Lupus erythematosus; Combined treatment; Disseminated
• ISSN: 1058-2916; 1538-943X
• DOI: 10.1097/00002480-200001000-00032

Diffuse alveolar hemorrhage secondary to systemic lupus erythematosus (SLE) may cause life-threatening respiratory failure and may be associated with multiple organ failure. Extensive support may be necessary to sustain life while systemic therapy becomes effective. We report here a patient with profound respiratory failure secondary to SLE associated with multiorgan failure, who was supported with veno-arterial extracorporeal lung assist (ECLA), veno-venous ECLA, and multiple continuous renal replacement therapies during plasmapheresis. The full spectrum of extracorporeal life support and treatment modalities was performed seamlessly by a single service within the critical care department.