Bioavailability and Tolerability of Topical and Oral Diclofenac Sodium Administration in Healthy Ponies

Aiming to characterize the bioavailability and assess the safety of topical and oral treatment of diclofenac sodium in healthy ponies, 18 animals were divided in three groups: one treated with topical (group I, n = 6), the second with oral diclofenac (group II, n = 6) at 2.5 mg/kg for 3 days, and th...

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Bibliographic Details
Published in:	Journal of equine veterinary science Vol. 33; no. 1; pp. 22 - 26
Main Authors:	Azevedo, Marcos S., De La Côrte, Flavio D., Brass, Karin E., Dalmora, Sergio L., Machado, Francine T., Pompermayer, Endrigo, Dau, Stefano L., Santa'Ana, Laureana A.
Format:	Journal Article
Language:	English
Published:	Elsevier Inc 01-01-2013
Subjects:	alkaline phosphatase bioavailability coagulation Concentration eosinophils fibrinogen hematocrit hemoglobin High-performance liquid chromatography Horses leukocyte count lymphocytes Nonsteroidal anti-inflammatory drugs oral administration Pharmacokinetics phenylbutazone prothrombin synovial fluid thromboplastin topical application Horses Nonsteroidal anti-inflammatory drugs Concentration Pharmacokinetics High-performance liquid chromatography
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