Mechanism involved in the anti-inflammatory effect of Spiranthera odoratissima (Manacá)
Acetic acid-induced writhing, hot-plate, carrageenan-induced pleurisy, formalin-induced pain, croton oil-induced ear edema, vascular permeability tests and phospholipase A2 activity assay were used to study the analgesic and/or anti-inflammatory activity of the hydromethanolic fraction of ethanolic...
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| Published in: | Revista brasileira de farmacognosia Vol. 22; no. 1; pp. 137 - 143 |
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| Language: | English |
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| Abstract | Acetic acid-induced writhing, hot-plate, carrageenan-induced pleurisy, formalin-induced pain, croton oil-induced ear edema, vascular permeability tests and phospholipase A2 activity assay were used to study the analgesic and/or anti-inflammatory activity of the hydromethanolic fraction of ethanolic extract from Spiranthera odoratissima A. St.-Hil., Rutaceae, leaves (HMF) and its subfraction (sub-Fr10-28). HMF and sub-Fr10-28 reduced the leukocyte migration on the carrageenan-induced pleurisy test; sub-Fr10-28 reduced the pain reaction time in the second phase of formalin-induced pain, as well as the ear edema and vascular permeability. Both HMF and sub-Fr10-28 inhibited the phospholipase A2 activity. These results suggest that the analgesic effect of this plant could be, in part, due to an anti-inflammatory action produced by the inhibition of phospholipase A2 activity. |
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| AbstractList | Acetic acid-induced writhing, hot-plate, carrageenan-induced pleurisy, formalin-induced pain, croton oil-induced ear edema, vascular permeability tests and phospholipase A2 activity assay were used to study the analgesic and/or anti-inflammatory activity of the hydromethanolic fraction of ethanolic extract from Spiranthera odoratissima A. St.-Hil., Rutaceae, leaves (HMF) and its subfraction (sub-Fr10-28). HMF and sub-Fr10-28 reduced the leukocyte migration on the carrageenan-induced pleurisy test; sub-Fr10-28 reduced the pain reaction time in the second phase of formalin-induced pain, as well as the ear edema and vascular permeability. Both HMF and sub-Fr10-28 inhibited the phospholipase A2 activity. These results suggest that the analgesic effect of this plant could be, in part, due to an anti-inflammatory action produced by the inhibition of phospholipase A2 activity. |
| Author | Lino, Roberta C. Florentino, Iziara F. Magalhães, Marta R. Galdino, Pablinny M. Barbosa, Daniela B. M. Paula, José R. de Honório, Tereza C. D. Nascimento, Marcus V. M. Bara, Maria Teresa F. Costa, Elson A. |
| AuthorAffiliation | Pontifícia Universidade Católica de Goiás Universidade Federal de Goiás |
| AuthorAffiliation_xml | – name: Pontifícia Universidade Católica de Goiás – name: Universidade Federal de Goiás |
| Author_xml | – sequence: 1 givenname: Daniela B. M. surname: Barbosa fullname: Barbosa, Daniela B. M. – sequence: 2 givenname: Marcus V. M. surname: Nascimento fullname: Nascimento, Marcus V. M. – sequence: 3 givenname: Roberta C. surname: Lino fullname: Lino, Roberta C. – sequence: 4 givenname: Marta R. surname: Magalhães fullname: Magalhães, Marta R. – sequence: 5 givenname: Iziara F. surname: Florentino fullname: Florentino, Iziara F. – sequence: 6 givenname: Tereza C. D. surname: Honório fullname: Honório, Tereza C. D. – sequence: 7 givenname: Pablinny M. surname: Galdino fullname: Galdino, Pablinny M. – sequence: 8 givenname: Maria Teresa F. surname: Bara fullname: Bara, Maria Teresa F. – sequence: 9 givenname: José R. de surname: Paula fullname: Paula, José R. de – sequence: 10 givenname: Elson A. surname: Costa fullname: Costa, Elson A. |
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| CitedBy_id | crossref_primary_10_1016_j_jep_2021_113979 crossref_primary_10_1111_j_2042_7158_2012_01582_x crossref_primary_10_1155_2014_429256 crossref_primary_10_1016_j_bjp_2017_10_010 crossref_primary_10_1600_036364422X16442668423365 crossref_primary_10_1007_s00580_019_03019_5 crossref_primary_10_1016_j_lfs_2012_12_003 crossref_primary_10_1590_2236_8906_123_2020 crossref_primary_10_1590_S1516_05722013000200009 crossref_primary_10_1590_S0001_37652013000300011 |
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| Keywords | anti-inflammatory medicinal plant antinociceptive Spiranthera odoratissima phospholipase A2 |
| Language | English |
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| Title | Mechanism involved in the anti-inflammatory effect of Spiranthera odoratissima (Manacá) |
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