Mechanism involved in the anti-inflammatory effect of Spiranthera odoratissima (Manacá)

• Published in: Revista brasileira de farmacognosia Vol. 22; no. 1; pp. 137 - 143
• Main Authors: Barbosa, Daniela B. M., Nascimento, Marcus V. M., Lino, Roberta C., Magalhães, Marta R., Florentino, Iziara F., Honório, Tereza C. D., Galdino, Pablinny M., Bara, Maria Teresa F., Paula, José R. de, Costa, Elson A.
• Format: Journal Article
• Language: English
• Published: Sociedade Brasileira de Farmacognosia 01-02-2012
• Subjects: PHARMACOLOGY & PHARMACY; anti-inflammatory; medicinal plant; antinociceptive; Spiranthera odoratissima; phospholipase A2
• ISSN: 0102-695X; 1981-528X
• DOI: 10.1590/S0102-695X2011005000154

Acetic acid-induced writhing, hot-plate, carrageenan-induced pleurisy, formalin-induced pain, croton oil-induced ear edema, vascular permeability tests and phospholipase A2 activity assay were used to study the analgesic and/or anti-inflammatory activity of the hydromethanolic fraction of ethanolic extract from Spiranthera odoratissima A. St.-Hil., Rutaceae, leaves (HMF) and its subfraction (sub-Fr10-28). HMF and sub-Fr10-28 reduced the leukocyte migration on the carrageenan-induced pleurisy test; sub-Fr10-28 reduced the pain reaction time in the second phase of formalin-induced pain, as well as the ear edema and vascular permeability. Both HMF and sub-Fr10-28 inhibited the phospholipase A2 activity. These results suggest that the analgesic effect of this plant could be, in part, due to an anti-inflammatory action produced by the inhibition of phospholipase A2 activity.