Stereochemical Stability of Planar-Chiral Benzazepine Tricyclics: Inversion Energies of P- and S-Alkene Ligands

• Published in: Journal of organic chemistry Vol. 88; no. 23; pp. 16144 - 16154
• Main Authors: Calderón, Jacqueline C., Herrera, Alberto, Heinemann, Frank W., Langer, Jens, Linden, Anthony, Chelouan, Ahmed, Grasruck, Alexander, Añez, Rafael, Clark, Timothy, Dorta, Romano
• Format: Journal Article
• Language: English
• Published: 01-12-2023
• ISSN: 0022-3263; 1520-6904
• DOI: 10.1021/acs.joc.3c01447

Inversion barriers ΔG‡ for planar chiral phosphine-alkene and sulfonamide-alkene hybrid ligands based on phenyl-dibenz[b,f]azepine have been determined by density-functional theory calculations. Analysis of the structural and electronic characteristics of the minima and transition states explains the magnitudes of ΔG‡ and the geometrical changes during the inversion process. The steric repulsion caused by bulky substituents attached to the azepine nitrogen atom has a pronounced effect on the ΔG‡ value, explaining, inter alia, the stereochemical stability of the P- and S-alkene ligands when compared to the fluxional parent compound where X = H.