A proton magnetic resonance spectroscopic study in ALS : Correlation with clinical findings

To evaluate neuronal dysfunction in the motor region subcortical white matter in ALS using volumetric localized proton magnetic resonance spectroscopy (1H-MRS). Sixteen patients with E1 Escorial definite, probable, or possible ALS and eight healthy age-matched control subjects were studied. The ALS...

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Bibliographic Details
Published in:	Neurology Vol. 51; no. 4; pp. 1104 - 1109
Main Authors:	ELLIS, C. M, SIMMONS, A, ANDREWS, C, DAWSON, J. M, WILLIAMS, S. C. R, LEIGH, P. N
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD Lippincott Williams & Wilkins 01-10-1998
Subjects:	Adult Aged Amyotrophic Lateral Sclerosis - diagnosis Amyotrophic Lateral Sclerosis - metabolism Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Biological and medical sciences Choline - metabolism Creatinine - metabolism Humans Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging - methods Medical sciences Middle Aged Motor Cortex - metabolism Nervous system Occipital Lobe - metabolism Parietal Lobe - metabolism Phosphocreatine - metabolism Protons Radiodiagnosis. Nmr imagery. Nmr spectrometry Human Volumetric analysis Nervous system diseases Exploration Amyotrophic lateral sclerosis NMR spectrometry Metabolism Nuclear magnetic resonance imaging White matter Sensitivity Motor cortex Central nervous system disease Proton Medical imagery Degenerative disease Severity score Spinal cord disease
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