Ecotoxicological studies of direct and indirect genotoxicity with Artemia: a integrative review

• Published in: Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering Vol. 59; no. 6; pp. 305 - 320
• Main Authors: Souza, Clessius Ribeiro de, Souza-Silva, Gabriel, Silva, Fernanda Viana Moreira, Cardoso, Paula von Randow, Lima, Walter dos Santos, Pereira, Cíntia Aparecida de Jesus, Mol, Marcos Paulo Gomes, Silveira, Micheline Rosa
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 11-05-2024; Taylor & Francis Ltd
• Subjects: Animals; Artemia; Artemia - drug effects; bioassays; Biological effects; Biomarkers; Biomonitoring; Brine shrimp; Chromosome aberrations; Damage detection; DNA Damage; Ecotoxicology; Environmental quality; enzymatic activity; Fecundity; Gene expression; Genetic analysis; Genetic variability; Genotoxicity; Metabolomics; Mutagenicity Tests; Mutagens - toxicity; Transcriptomics; Water Pollutants, Chemical - toxicity; enzymatic activity; Brine shrimp; bioassays; ecotoxicology; gene expression
• ISSN: 1093-4529; 1532-4117; 1532-4117
• DOI: 10.1080/10934529.2024.2384216

Artemia is a brine shrimp genus adapted to extreme habitats like ranges salinity from 5-25 g/L and in temperatures from 9 to 35 °C. It is widely distributed and used as an environmental quality biomarker. Artemia franciscana and Artemia salina species are commonly used in ecotoxicological studies and genotoxicity assays due to their short life cycle, high fecundity rate, easy culture, and availability. Thus, considering the importance of these tests in ecotoxicological studies, the present study aimed to present Artemia genus as a biological model in genotoxicity research. To this end, we reviewed the literature, analyzing data published until July 2023 in the Web of Science, SCOPUS, Embase, and PubMed databases. After screening, we selected 34 studies in which the genotoxicity of Artemia for various substances. This review presents the variability of the experimental planning of assays and biomarkers in genotoxicity using Artemia genus as a biological model for ecotoxicological studies and show the possibility of monitoring biochemical alterations and genetic damage effects. Also highlight innovative technologies such as transcriptomic and metabolomic analysis, as well as studies over successive generations to identify changes in DNA and consequently in gene expression.