Installation and use of LabKey Server for proteomics

• Published in: Current protocols in bioinformatics Vol. Chapter 13; p. 13.5.1
• Main Authors: Eckels, Joshua, Hussey, Peter, Nelson, Elizabeth K, Myers, Tamra, Rauch, Adam, Bellew, Matthew, Connolly, Brian, Law, Wendy, Eng, Jimmy K, Katz, Jonathan, McIntosh, Martin, Mallick, Parag, Igra, Mark
• Format: Journal Article
• Language: English
• Published: United States 01-12-2011
• Subjects: Chromatography, Liquid - methods; Data Mining; Databases, Protein; Mass Spectrometry - methods; Proteomics - instrumentation; Proteomics - methods; Software
• ISSN: 1934-340X
• DOI: 10.1002/0471250953.bi1305s36

LabKey Server (formerly CPAS, the Computational Proteomics Analysis System) provides a Web-based platform for mining data from liquid chromatography-tandem mass spectrometry (LC-MS/MS) proteomic experiments. This open source platform supports systematic proteomic analyses and secure data management, integration, and sharing. LabKey Server incorporates several tools currently used in proteomic analysis, including the X! Tandem search engine, the ProteoWizard toolkit, and the PeptideProphet and ProteinProphet data mining tools. These tools and others are integrated into LabKey Server, which provides an extensible architecture for developing high-throughput biological applications. The LabKey Server analysis pipeline acts on data in standardized file formats, so that researchers may use LabKey Server with other search engines, including Mascot or SEQUEST, that follow a standardized format for reporting search engine results. Supported builds of LabKey Server are freely available at http://www.labkey.com/. Documentation and source code are available under the Apache License 2.0 at http://www.labkey.org.