Analysis of metabolic compounds and antitumorigenic effects of Albizia niopoides and Senegalia polyphylla leaves

• Published in: Natural product research pp. 1 - 8
• Main Authors: Cagnin Pereira, Thalissa, Cardoso, Luana Pereira, da Silva de Paiva, Wesller, Santos de Camargos, Liliane, Cristina Rodrigues-Lisoni, Flávia, Redondo Martins, Aline
• Format: Journal Article
• Language: English
• Published: England 26-03-2024
• Subjects: SiHa; phenolic compounds; Antiproliferative effect; cell morphology; fabaceae
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2024.2331603

The objective of this study was to quantify metabolic compounds in leaves of
and
and to evaluate the antitumor potential of extracts from both species in cervical tumour cells. The physiological analyses performed were quantification of starch, sucrose, phenolic compounds and proteins. An aqueous extract was prepared and added to the SiHa cell line at concentrations of 10, 100 and 1000 μg/mL at 4h, 24h, 48h and 72h. Cell morphology, proliferation and viability were analysed. The species showed a large amount of starch and phenolic compounds. Treatment with the extract of both species caused morphological changes in SiHa cells and exhibited antiproliferative effects at a concentration of 1000 µg/ml. In cell viability test, only
showed a significant reduction. The study presented the effects of the species against a cervical cancer cell line, where
has already shown to be a promising plant drug.