Evidence for a role of endorphins in stress- and suckling-induced prolactin release in the rat

Injection of the opiate antagonist naloxone completely prevented the rise of serum prolactin induced by ether stress in intact male rats. Naloxone also led to a 50--95% inhibition of the marked elevation of plasma prolactin levels induced by suckling. These data suggest that endogenous opiates (endo...

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Bibliographic Details
Published in:	Molecular and cellular endocrinology Vol. 12; no. 3; p. 267
Main Authors:	Ferland, L, Kledzik, G S, Cusan, L, Labrie, F
Format:	Journal Article
Language:	English
Published:	Ireland 01-12-1978
Subjects:	Animals Animals, Suckling Endorphins - physiology Ether Female Lactation Male Naloxone - pharmacology Pregnancy Prolactin - metabolism Rats Stress, Physiological - chemically induced Stress, Physiological - physiopathology
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Summary:	Injection of the opiate antagonist naloxone completely prevented the rise of serum prolactin induced by ether stress in intact male rats. Naloxone also led to a 50--95% inhibition of the marked elevation of plasma prolactin levels induced by suckling. These data suggest that endogenous opiates (endorphins) are involved in the stimulation of prolactin release induced by both stress and suckling in the rat.
ISSN:	0303-7207
DOI:	10.1016/0303-7207(78)90085-0