Spectroscopic Characterization of the SH2- and Active Site-Directed Peptide Sequences of a Bivalent Src Kinase Inhibitor

The spectral properties of the SH2 and active site-directed sequences of the bivalent Src kinase inhibitor Ac-EELL(F5)Phe-(GABA)3-pYEEIE-amide (1) have been determined. Ac-pYEEIE-amide (2) and Ac-EELL(F5)Phe-amide (3), as well as the amino acids phosphotyrosine (pTyr) and pentafluorophenylalanine (F...

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Bibliographic Details
Published in:	Applied spectroscopy Vol. 63; no. 7; pp. 767 - 774
Main Authors:	Desamero, Ruel Z. B., Kang, Jeonghee, Dol, Chrystel, Chinwong, Justina, Walters, Karim, Sivarajah, Thulashie, Profit, Adam A.
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-07-2009
Subjects:	Catalytic Domain Computer Simulation Models, Chemical Peptides - chemistry Peptides - pharmacology Phenylalanine - chemistry Phosphotyrosine - chemistry Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Solvents - chemistry Spectroscopy, Fourier Transform Infrared - methods src Homology Domains src-Family Kinases - antagonists & inhibitors src-Family Kinases - chemistry src-Family Kinases - metabolism FT-IR spectroscopy DFT Phosphotyrosine Pentafluorophenylalanine Bivalent inhibitors Fluorescence Src kinase Density functional theory Fourier transform infrared spectroscopy
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