Does race affect the long-term survival benefit of systemic therapy in pancreatic adenocarcinoma?
Systemic therapy is a key management component of pancreatic ductal adenocarcinoma(PDAC). Racial disparities exist in PDAC, often linked to socioeconomic variables. We investigated the impact of race in PDAC patients who had undergone systemic therapy and surgical resection. A retrospective analysis...
Saved in:
Published in: | The American journal of surgery Vol. 224; no. 3; pp. 955 - 958 |
---|---|
Main Authors: | , , , , , , , , , , |
Format: | Journal Article |
Language: | English |
Published: |
United States
Elsevier Inc
01-09-2022
Elsevier Limited |
Subjects: | |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Abstract | Systemic therapy is a key management component of pancreatic ductal adenocarcinoma(PDAC). Racial disparities exist in PDAC, often linked to socioeconomic variables. We investigated the impact of race in PDAC patients who had undergone systemic therapy and surgical resection.
A retrospective analysis was performed for all patients who underwent surgical resection for PDAC from 2010 to 2018.
234 patients (78.2% White; 21.8% Black) were included. Black patients presented at a younger age with larger tumors. White patients benefited from systemic therapy with longer overall survival (35vs20 months, p = 0.002). This survival advantage was not present in Black patients (21vs15 months, p = 0.15). Black patients receiving systemic therapy had similar survival as White patients who did not (p = 0.81).
Black PDAC patients present at younger ages and with larger initial tumors. In our population, White patients had a longer overall survival after both surgical and systemic therapy. These findings may indicate differences in tumor biology. Further prospective studies are needed.
•Pancreatic Cancer is increasingly viewed as a systemic disease, with chemotherapy a key component of treatment.•Known racial disparities exist in the outcomes from pancreatic cancer, often linked to socioeconomic variables.•In patients undergoing surgery and systemic therapy, White patients were found to have improved survival compared to Black.•Differences in tumour biology may account for these differences, but controlled prospective studies are needed. |
---|---|
AbstractList | Systemic therapy is a key management component of pancreatic ductal adenocarcinoma(PDAC). Racial disparities exist in PDAC, often linked to socioeconomic variables. We investigated the impact of race in PDAC patients who had undergone systemic therapy and surgical resection.
A retrospective analysis was performed for all patients who underwent surgical resection for PDAC from 2010 to 2018.
234 patients (78.2% White; 21.8% Black) were included. Black patients presented at a younger age with larger tumors. White patients benefited from systemic therapy with longer overall survival (35vs20 months, p = 0.002). This survival advantage was not present in Black patients (21vs15 months, p = 0.15). Black patients receiving systemic therapy had similar survival as White patients who did not (p = 0.81).
Black PDAC patients present at younger ages and with larger initial tumors. In our population, White patients had a longer overall survival after both surgical and systemic therapy. These findings may indicate differences in tumor biology. Further prospective studies are needed. BACKGROUNDSystemic therapy is a key management component of pancreatic ductal adenocarcinoma(PDAC). Racial disparities exist in PDAC, often linked to socioeconomic variables. We investigated the impact of race in PDAC patients who had undergone systemic therapy and surgical resection.METHODSA retrospective analysis was performed for all patients who underwent surgical resection for PDAC from 2010 to 2018.RESULTS234 patients (78.2% White; 21.8% Black) were included. Black patients presented at a younger age with larger tumors. White patients benefited from systemic therapy with longer overall survival (35vs20 months, p = 0.002). This survival advantage was not present in Black patients (21vs15 months, p = 0.15). Black patients receiving systemic therapy had similar survival as White patients who did not (p = 0.81).CONCLUSIONBlack PDAC patients present at younger ages and with larger initial tumors. In our population, White patients had a longer overall survival after both surgical and systemic therapy. These findings may indicate differences in tumor biology. Further prospective studies are needed. Systemic therapy is a key management component of pancreatic ductal adenocarcinoma(PDAC). Racial disparities exist in PDAC, often linked to socioeconomic variables. We investigated the impact of race in PDAC patients who had undergone systemic therapy and surgical resection. A retrospective analysis was performed for all patients who underwent surgical resection for PDAC from 2010 to 2018. 234 patients (78.2% White; 21.8% Black) were included. Black patients presented at a younger age with larger tumors. White patients benefited from systemic therapy with longer overall survival (35vs20 months, p = 0.002). This survival advantage was not present in Black patients (21vs15 months, p = 0.15). Black patients receiving systemic therapy had similar survival as White patients who did not (p = 0.81). Black PDAC patients present at younger ages and with larger initial tumors. In our population, White patients had a longer overall survival after both surgical and systemic therapy. These findings may indicate differences in tumor biology. Further prospective studies are needed. •Pancreatic Cancer is increasingly viewed as a systemic disease, with chemotherapy a key component of treatment.•Known racial disparities exist in the outcomes from pancreatic cancer, often linked to socioeconomic variables.•In patients undergoing surgery and systemic therapy, White patients were found to have improved survival compared to Black.•Differences in tumour biology may account for these differences, but controlled prospective studies are needed. |
Author | Irfan, Ahmer Rose, J. Bart Reddy, Sushanth Vickers, Selwyn M. Williams, Grant R. Fang, Hua A. Gbolahan, Olumide Nien-Tsu Wang, Thomas Awad, Seifeldin Dudeja, Vikas Alkashah, Ahmad |
Author_xml | – sequence: 1 givenname: Ahmer orcidid: 0000-0001-8339-652X surname: Irfan fullname: Irfan, Ahmer email: airfan@uabmc.edu organization: Department of General Surgery, University of Alabama at Birmingham, Birmingham, AL, USA – sequence: 2 givenname: Hua A. surname: Fang fullname: Fang, Hua A. organization: Department of General Surgery, University of Alabama at Birmingham, Birmingham, AL, USA – sequence: 3 givenname: Seifeldin surname: Awad fullname: Awad, Seifeldin organization: O'Neal Comprehensive Cancer Center at the University of Alabama at Birmingham, Birmingham, AL, USA – sequence: 4 givenname: Ahmad surname: Alkashah fullname: Alkashah, Ahmad organization: O'Neal Comprehensive Cancer Center at the University of Alabama at Birmingham, Birmingham, AL, USA – sequence: 5 givenname: Selwyn M. surname: Vickers fullname: Vickers, Selwyn M. organization: Department of General Surgery, University of Alabama at Birmingham, Birmingham, AL, USA – sequence: 6 givenname: Olumide surname: Gbolahan fullname: Gbolahan, Olumide organization: O'Neal Comprehensive Cancer Center at the University of Alabama at Birmingham, Birmingham, AL, USA – sequence: 7 givenname: Grant R. surname: Williams fullname: Williams, Grant R. organization: O'Neal Comprehensive Cancer Center at the University of Alabama at Birmingham, Birmingham, AL, USA – sequence: 8 givenname: Thomas surname: Nien-Tsu Wang fullname: Nien-Tsu Wang, Thomas organization: Department of General Surgery, University of Alabama at Birmingham, Birmingham, AL, USA – sequence: 9 givenname: Vikas surname: Dudeja fullname: Dudeja, Vikas organization: Department of General Surgery, University of Alabama at Birmingham, Birmingham, AL, USA – sequence: 10 givenname: J. Bart surname: Rose fullname: Rose, J. Bart organization: Department of General Surgery, University of Alabama at Birmingham, Birmingham, AL, USA – sequence: 11 givenname: Sushanth surname: Reddy fullname: Reddy, Sushanth organization: Department of General Surgery, University of Alabama at Birmingham, Birmingham, AL, USA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35430088$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkU2LFDEQhoOsuLOrP0EJePHSbSXpj8xpkV2_YMGLnkO6urKm6U7GpGdg_r0ZZvTgxVOR4qmq8D437CrEQIy9FlALEN37qbbLlPfpqZYgZQ1NDdA8Yxuh-20ltFZXbAMAstp2Aq7ZTc5TeQrRqBfsWrWNAtB6w-xDpMyTReLWOcKVrz-JzzE8VSulhZcLB3-wMx8okPMrj47nY15p8XhCk90duQ98ZwMmsmvp2pFCRJvQh7jYu5fsubNzpleXest-fPr4_f5L9fjt89f7D48Vyl6slezGgbQVAyrX2GHQvRxcLxSSROk6Lci1VkELWg0oAR1ph1Y2toMBsVHqlr07792l-GtPeTWLz0jzbAPFfTaya0tSuuv7gr79B53iPoXyOyN76HrYai0L1Z4pTDHnRM7skl9sOhoB5uTATObiwJwcGGhMcVDm3ly274eFxr9Tf0IvwN0ZoBLHwVMyGT0FpNGnYsCM0f_nxG-4e52k |
Cites_doi | 10.1097/00001648-200301000-00013 10.1158/1078-0432.CCR-11-1539 10.1002/jso.26383 10.1056/NEJMoa032295 10.1016/j.cgh.2019.05.059 10.1097/SLA.0b013e3180691579 10.1001/jamasurg.2019.5047 10.1093/annonc/mdp290 10.1177/107327481602300405 10.1097/MD.0000000000003315 10.1038/nature16965 10.1097/00006676-200301000-00006 10.1038/srep06747 10.1080/02732173.2016.1227283 10.1158/0008-5472.CAN-14-0155 10.1001/jama.2013.279201 10.1245/s10434-009-0656-5 10.1016/j.molonc.2016.05.004 10.1007/s10620-018-5291-1 10.1093/jnci/djt292 10.3322/caac.21551 10.1002/ijc.25822 10.1038/ncomms8686 |
ContentType | Journal Article |
Copyright | 2022 Elsevier Inc. Copyright © 2022 Elsevier Inc. All rights reserved. 2022. Elsevier Inc. |
Copyright_xml | – notice: 2022 Elsevier Inc. – notice: Copyright © 2022 Elsevier Inc. All rights reserved. – notice: 2022. Elsevier Inc. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7QO 7X7 7XB 88E 8FD 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH K9. M0S M1P M2O MBDVC P64 PQEST PQQKQ PQUKI PRINS Q9U 7X8 |
DOI | 10.1016/j.amjsurg.2022.04.004 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Biotechnology Research Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Technology Research Database Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials AUTh Library subscriptions: ProQuest Central ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) ProQuest research library Research Library (Corporate) Biotechnology and BioEngineering Abstracts ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Research Library Prep ProQuest Central Student Technology Research Database ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College Research Library (Alumni Edition) ProQuest Central China ProQuest Central Health Research Premium Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Research Library ProQuest Medical Library (Alumni) ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | MEDLINE MEDLINE - Academic Research Library Prep |
Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
EISSN | 1879-1883 |
EndPage | 958 |
ExternalDocumentID | 10_1016_j_amjsurg_2022_04_004 35430088 S0002961022002409 |
Genre | Journal Article |
GeographicLocations | United States--US |
GeographicLocations_xml | – name: United States--US |
GroupedDBID | --- --K --M .1- .55 .FO .GJ .~1 0R~ 123 1B1 1CY 1P~ 1RT 1~. 1~5 23M 3V. 4.4 457 4CK 4G. 53G 5RE 5VS 6J9 7-5 71M 7X7 85S 88E 8FI 8FJ 8G5 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQQT AAQXK AAWTL AAXUO ABBQC ABFNM ABLJU ABLVK ABMAC ABMZM ABOCM ABUWG ABXDB ABYKQ ACDAQ ACIUM ACIWK ACPRK ACRLP ADBBV ADEZE ADFRT ADMUD AEBSH AEKER AENEX AEVXI AFFNX AFKRA AFKWA AFRAH AFRHN AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AHMBA AHPSJ AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY AJUYK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN AZQEC BENPR BKOJK BLXMC BNPGV BPHCQ BVXVI CCPQU CS3 DWQXO EBS EFJIC EFLBG EJD EMOBN EO8 EO9 EP2 EP3 EX3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN FYUFA G-2 G-Q G8K GBLVA GNUQQ GUQSH HEK HMCUK HMK HMO HVGLF HZ~ IH2 IHE J1W J5H K-O KOM L7B LCYCR M1P M29 M2O M41 MO0 N4W N9A O-L O9- OAUVE OJ0 OV0 OZT P-8 P-9 P2P PC. PQQKQ PROAC PSQYO Q38 R2- RIG ROL RPZ SAE SCC SDF SDG SDP SEL SES SPCBC SSH SSZ SV3 T5K TWZ UHU UKHRP UNMZH UV1 WH7 WOW WUQ X7M XPP YOC YQJ Z5R ZA5 ZCG ZGI ZXP ~G- AAXKI ABDPE AFCTW AFJKZ AKRWK ALIPV CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QO 7XB 8FD 8FK FR3 K9. MBDVC P64 PQEST PQUKI PRINS Q9U 7X8 |
ID | FETCH-LOGICAL-c271t-26dbe8a1bc3f4abb872bf713ce2c2f681ef5a305083bc20cfe8fca24a60bcc433 |
ISSN | 0002-9610 |
IngestDate | Fri Oct 25 21:08:54 EDT 2024 Thu Oct 10 22:14:56 EDT 2024 Fri Nov 22 00:28:56 EST 2024 Sat Nov 02 12:20:12 EDT 2024 Fri Feb 23 02:39:43 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 3 |
Keywords | Pancreatic adenocarcinoma PDAC Adjuvant therapy UAB Disparities in care |
Language | English |
License | Copyright © 2022 Elsevier Inc. All rights reserved. |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c271t-26dbe8a1bc3f4abb872bf713ce2c2f681ef5a305083bc20cfe8fca24a60bcc433 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0001-8339-652X |
PMID | 35430088 |
PQID | 2706709882 |
PQPubID | 1216386 |
PageCount | 4 |
ParticipantIDs | proquest_miscellaneous_2652028677 proquest_journals_2706709882 crossref_primary_10_1016_j_amjsurg_2022_04_004 pubmed_primary_35430088 elsevier_sciencedirect_doi_10_1016_j_amjsurg_2022_04_004 |
PublicationCentury | 2000 |
PublicationDate | September 2022 2022-09-00 20220901 |
PublicationDateYYYYMMDD | 2022-09-01 |
PublicationDate_xml | – month: 09 year: 2022 text: September 2022 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States – name: New York |
PublicationTitle | The American journal of surgery |
PublicationTitleAlternate | Am J Surg |
PublicationYear | 2022 |
Publisher | Elsevier Inc Elsevier Limited |
Publisher_xml | – name: Elsevier Inc – name: Elsevier Limited |
References | Neoptolemos (bib4) 2004; 350 Bailey (bib21) 2016; 531 Mitsakos, Dennis, Parikh, Snyder (bib17) 2021; 123 Adelman, Tsao (bib19) 2016; 36 Sun, Ma, Hong, Sun, Wang (bib16) 2014; 4 Schabath, Cress, Munoz-Antonia (bib10) 2016; 23 Sausen (bib22) 2015; 6 Rahib (bib2) 2014; 74 Silverman (bib12) 2003; 14 Ma, Siegel, Jemal (bib7) 2013; 105 Donahue (bib20) 2012; 18 Siegel, Miller, Jemal (bib1) 2019; 69 Oettle (bib3) 2013; 310 Pernick (bib24) 2003; 26 Kirby (bib23) 2016; 10 Cervantes, Waymouth, Petrov (bib5) 2019; 64 Tavakkoli (bib6) 2020; 18 Ollberding, Nomura, Wilkens, Henderson, Kolonel (bib11) 2011; 129 Bilimoria (bib13) 2007; 246 United States Census Bureau. Quick Facts: United States. Heller, Nicolson, Ahuja, Khan, Kunstman (bib15) 2020; 155 . Kim (bib9) 2010; 21 Ward-Peterson (bib8) 2016; 95 Murphy (bib14) 2009; 16 Tavakkoli (10.1016/j.amjsurg.2022.04.004_bib6) 2020; 18 10.1016/j.amjsurg.2022.04.004_bib18 Sun (10.1016/j.amjsurg.2022.04.004_bib16) 2014; 4 Neoptolemos (10.1016/j.amjsurg.2022.04.004_bib4) 2004; 350 Bailey (10.1016/j.amjsurg.2022.04.004_bib21) 2016; 531 Donahue (10.1016/j.amjsurg.2022.04.004_bib20) 2012; 18 Ollberding (10.1016/j.amjsurg.2022.04.004_bib11) 2011; 129 Murphy (10.1016/j.amjsurg.2022.04.004_bib14) 2009; 16 Schabath (10.1016/j.amjsurg.2022.04.004_bib10) 2016; 23 Adelman (10.1016/j.amjsurg.2022.04.004_bib19) 2016; 36 Cervantes (10.1016/j.amjsurg.2022.04.004_bib5) 2019; 64 Pernick (10.1016/j.amjsurg.2022.04.004_bib24) 2003; 26 Siegel (10.1016/j.amjsurg.2022.04.004_bib1) 2019; 69 Bilimoria (10.1016/j.amjsurg.2022.04.004_bib13) 2007; 246 Oettle (10.1016/j.amjsurg.2022.04.004_bib3) 2013; 310 Silverman (10.1016/j.amjsurg.2022.04.004_bib12) 2003; 14 Sausen (10.1016/j.amjsurg.2022.04.004_bib22) 2015; 6 Rahib (10.1016/j.amjsurg.2022.04.004_bib2) 2014; 74 Ma (10.1016/j.amjsurg.2022.04.004_bib7) 2013; 105 Kirby (10.1016/j.amjsurg.2022.04.004_bib23) 2016; 10 Mitsakos (10.1016/j.amjsurg.2022.04.004_bib17) 2021; 123 Kim (10.1016/j.amjsurg.2022.04.004_bib9) 2010; 21 Heller (10.1016/j.amjsurg.2022.04.004_bib15) 2020; 155 Ward-Peterson (10.1016/j.amjsurg.2022.04.004_bib8) 2016; 95 |
References_xml | – volume: 129 start-page: 1899 year: 2011 end-page: 1906 ident: bib11 article-title: Racial/ethnic differences in colorectal cancer risk: the multiethnic cohort study publication-title: Int J Cancer contributor: fullname: Kolonel – volume: 26 start-page: 28 year: 2003 end-page: 32 ident: bib24 article-title: Clinicopathologic analysis of pancreatic adenocarcinoma in African Americans and Caucasians publication-title: Pancreas contributor: fullname: Pernick – volume: 246 start-page: 173 year: 2007 end-page: 180 ident: bib13 article-title: National failure to operate on early stage pancreatic cancer publication-title: Ann Surg contributor: fullname: Bilimoria – volume: 123 start-page: 970 year: 2021 end-page: 977 ident: bib17 article-title: Thirty-day complication rates do not differ by race among patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma publication-title: J Surg Oncol contributor: fullname: Snyder – volume: 95 year: 2016 ident: bib8 article-title: Association between race/ethnicity and survival of melanoma patients in the United States over 3 decades: a secondary analysis of SEER data publication-title: Medicine (Baltim) contributor: fullname: Ward-Peterson – volume: 21 start-page: 152 year: 2010 end-page: 160 ident: bib9 article-title: Race and ethnicity correlate with survival in patients with gastric adenocarcinoma publication-title: Ann Oncol contributor: fullname: Kim – volume: 14 year: 2003 ident: bib12 article-title: Why do Black Americans have a higher risk of pancreatic cancer than white Americans? publication-title: Epidemiology contributor: fullname: Silverman – volume: 4 start-page: 6747 year: 2014 ident: bib16 article-title: J. Survival improvement in patients with pancreatic cancer by decade: a period analysis of the SEER database, 1981-2010 publication-title: Sci Rep contributor: fullname: Wang – volume: 310 start-page: 1473 year: 2013 end-page: 1481 ident: bib3 article-title: Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial publication-title: JAMA contributor: fullname: Oettle – volume: 69 start-page: 7 year: 2019 end-page: 34 ident: bib1 article-title: Cancer statistics publication-title: CA Cancer J Clin contributor: fullname: Jemal – volume: 350 start-page: 1200 year: 2004 end-page: 1210 ident: bib4 article-title: A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer publication-title: N Engl J Med contributor: fullname: Neoptolemos – volume: 64 start-page: 249 year: 2019 end-page: 261 ident: bib5 article-title: African-Americans and indigenous peoples have increased burden of diseases of the exocrine pancreas: a systematic review and meta-analysis publication-title: Dig Dis Sci contributor: fullname: Petrov – volume: 6 start-page: 7686 year: 2015 ident: bib22 article-title: Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients publication-title: Nat Commun contributor: fullname: Sausen – volume: 36 start-page: 337 year: 2016 end-page: 358 ident: bib19 article-title: Deep South demography: new immigrants and racial hierarchies publication-title: Socio Spectr contributor: fullname: Tsao – volume: 105 start-page: 1694 year: 2013 end-page: 1700 ident: bib7 article-title: Pancreatic cancer death rates by race among US men and women, 1970-2009 publication-title: J Natl Cancer Inst contributor: fullname: Jemal – volume: 23 start-page: 338 year: 2016 end-page: 346 ident: bib10 article-title: Racial and ethnic differences in the epidemiology and genomics of lung cancer publication-title: Cancer Control contributor: fullname: Munoz-Antonia – volume: 18 start-page: 1352 year: 2012 end-page: 1363 ident: bib20 article-title: Integrative survival-based molecular profiling of human pancreatic cancer publication-title: Clin Cancer Res contributor: fullname: Donahue – volume: 155 year: 2020 ident: bib15 article-title: Association of treatment inequity and ancestry with pancreatic ductal adenocarcinoma survival publication-title: JAMA Surgery contributor: fullname: Kunstman – volume: 531 start-page: 47 year: 2016 end-page: 52 ident: bib21 article-title: Genomic analyses identify molecular subtypes of pancreatic cancer publication-title: Nature contributor: fullname: Bailey – volume: 10 start-page: 1169 year: 2016 end-page: 1182 ident: bib23 article-title: RNA sequencing of pancreatic adenocarcinoma tumors yields novel expression patterns associated with long-term survival and reveals a role for ANGPTL4 publication-title: Mol Oncol contributor: fullname: Kirby – volume: 18 start-page: 171 year: 2020 end-page: 178.e10 ident: bib6 article-title: Racial disparities and trends in pancreatic cancer incidence and mortality in the United States publication-title: Clin Gastroenterol Hepatol contributor: fullname: Tavakkoli – volume: 74 start-page: 2913 year: 2014 end-page: 2921 ident: bib2 article-title: Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States publication-title: Cancer Res contributor: fullname: Rahib – volume: 16 start-page: 2968 year: 2009 end-page: 2977 ident: bib14 article-title: Racial differences in cancer specialist consultation, treatment, and outcomes for locoregional pancreatic adenocarcinoma publication-title: Ann Surg Oncol contributor: fullname: Murphy – volume: 14 year: 2003 ident: 10.1016/j.amjsurg.2022.04.004_bib12 article-title: Why do Black Americans have a higher risk of pancreatic cancer than white Americans? publication-title: Epidemiology doi: 10.1097/00001648-200301000-00013 contributor: fullname: Silverman – volume: 18 start-page: 1352 year: 2012 ident: 10.1016/j.amjsurg.2022.04.004_bib20 article-title: Integrative survival-based molecular profiling of human pancreatic cancer publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-11-1539 contributor: fullname: Donahue – volume: 123 start-page: 970 year: 2021 ident: 10.1016/j.amjsurg.2022.04.004_bib17 article-title: Thirty-day complication rates do not differ by race among patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma publication-title: J Surg Oncol doi: 10.1002/jso.26383 contributor: fullname: Mitsakos – volume: 350 start-page: 1200 year: 2004 ident: 10.1016/j.amjsurg.2022.04.004_bib4 article-title: A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer publication-title: N Engl J Med doi: 10.1056/NEJMoa032295 contributor: fullname: Neoptolemos – volume: 18 start-page: 171 year: 2020 ident: 10.1016/j.amjsurg.2022.04.004_bib6 article-title: Racial disparities and trends in pancreatic cancer incidence and mortality in the United States publication-title: Clin Gastroenterol Hepatol doi: 10.1016/j.cgh.2019.05.059 contributor: fullname: Tavakkoli – volume: 246 start-page: 173 year: 2007 ident: 10.1016/j.amjsurg.2022.04.004_bib13 article-title: National failure to operate on early stage pancreatic cancer publication-title: Ann Surg doi: 10.1097/SLA.0b013e3180691579 contributor: fullname: Bilimoria – volume: 155 year: 2020 ident: 10.1016/j.amjsurg.2022.04.004_bib15 article-title: Association of treatment inequity and ancestry with pancreatic ductal adenocarcinoma survival publication-title: JAMA Surgery doi: 10.1001/jamasurg.2019.5047 contributor: fullname: Heller – volume: 21 start-page: 152 year: 2010 ident: 10.1016/j.amjsurg.2022.04.004_bib9 article-title: Race and ethnicity correlate with survival in patients with gastric adenocarcinoma publication-title: Ann Oncol doi: 10.1093/annonc/mdp290 contributor: fullname: Kim – volume: 23 start-page: 338 year: 2016 ident: 10.1016/j.amjsurg.2022.04.004_bib10 article-title: Racial and ethnic differences in the epidemiology and genomics of lung cancer publication-title: Cancer Control doi: 10.1177/107327481602300405 contributor: fullname: Schabath – volume: 95 year: 2016 ident: 10.1016/j.amjsurg.2022.04.004_bib8 article-title: Association between race/ethnicity and survival of melanoma patients in the United States over 3 decades: a secondary analysis of SEER data publication-title: Medicine (Baltim) doi: 10.1097/MD.0000000000003315 contributor: fullname: Ward-Peterson – volume: 531 start-page: 47 year: 2016 ident: 10.1016/j.amjsurg.2022.04.004_bib21 article-title: Genomic analyses identify molecular subtypes of pancreatic cancer publication-title: Nature doi: 10.1038/nature16965 contributor: fullname: Bailey – volume: 26 start-page: 28 year: 2003 ident: 10.1016/j.amjsurg.2022.04.004_bib24 article-title: Clinicopathologic analysis of pancreatic adenocarcinoma in African Americans and Caucasians publication-title: Pancreas doi: 10.1097/00006676-200301000-00006 contributor: fullname: Pernick – volume: 4 start-page: 6747 year: 2014 ident: 10.1016/j.amjsurg.2022.04.004_bib16 article-title: J. Survival improvement in patients with pancreatic cancer by decade: a period analysis of the SEER database, 1981-2010 publication-title: Sci Rep doi: 10.1038/srep06747 contributor: fullname: Sun – ident: 10.1016/j.amjsurg.2022.04.004_bib18 – volume: 36 start-page: 337 year: 2016 ident: 10.1016/j.amjsurg.2022.04.004_bib19 article-title: Deep South demography: new immigrants and racial hierarchies publication-title: Socio Spectr doi: 10.1080/02732173.2016.1227283 contributor: fullname: Adelman – volume: 74 start-page: 2913 year: 2014 ident: 10.1016/j.amjsurg.2022.04.004_bib2 article-title: Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-14-0155 contributor: fullname: Rahib – volume: 310 start-page: 1473 year: 2013 ident: 10.1016/j.amjsurg.2022.04.004_bib3 article-title: Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial publication-title: JAMA doi: 10.1001/jama.2013.279201 contributor: fullname: Oettle – volume: 16 start-page: 2968 year: 2009 ident: 10.1016/j.amjsurg.2022.04.004_bib14 article-title: Racial differences in cancer specialist consultation, treatment, and outcomes for locoregional pancreatic adenocarcinoma publication-title: Ann Surg Oncol doi: 10.1245/s10434-009-0656-5 contributor: fullname: Murphy – volume: 10 start-page: 1169 year: 2016 ident: 10.1016/j.amjsurg.2022.04.004_bib23 article-title: RNA sequencing of pancreatic adenocarcinoma tumors yields novel expression patterns associated with long-term survival and reveals a role for ANGPTL4 publication-title: Mol Oncol doi: 10.1016/j.molonc.2016.05.004 contributor: fullname: Kirby – volume: 64 start-page: 249 year: 2019 ident: 10.1016/j.amjsurg.2022.04.004_bib5 article-title: African-Americans and indigenous peoples have increased burden of diseases of the exocrine pancreas: a systematic review and meta-analysis publication-title: Dig Dis Sci doi: 10.1007/s10620-018-5291-1 contributor: fullname: Cervantes – volume: 105 start-page: 1694 year: 2013 ident: 10.1016/j.amjsurg.2022.04.004_bib7 article-title: Pancreatic cancer death rates by race among US men and women, 1970-2009 publication-title: J Natl Cancer Inst doi: 10.1093/jnci/djt292 contributor: fullname: Ma – volume: 69 start-page: 7 year: 2019 ident: 10.1016/j.amjsurg.2022.04.004_bib1 article-title: Cancer statistics publication-title: CA Cancer J Clin doi: 10.3322/caac.21551 contributor: fullname: Siegel – volume: 129 start-page: 1899 year: 2011 ident: 10.1016/j.amjsurg.2022.04.004_bib11 article-title: Racial/ethnic differences in colorectal cancer risk: the multiethnic cohort study publication-title: Int J Cancer doi: 10.1002/ijc.25822 contributor: fullname: Ollberding – volume: 6 start-page: 7686 year: 2015 ident: 10.1016/j.amjsurg.2022.04.004_bib22 article-title: Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients publication-title: Nat Commun doi: 10.1038/ncomms8686 contributor: fullname: Sausen |
SSID | ssj0001143 |
Score | 2.4360793 |
Snippet | Systemic therapy is a key management component of pancreatic ductal adenocarcinoma(PDAC). Racial disparities exist in PDAC, often linked to socioeconomic... BackgroundSystemic therapy is a key management component of pancreatic ductal adenocarcinoma(PDAC). Racial disparities exist in PDAC, often linked to... BACKGROUNDSystemic therapy is a key management component of pancreatic ductal adenocarcinoma(PDAC). Racial disparities exist in PDAC, often linked to... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 955 |
SubjectTerms | Adenocarcinoma Adjuvant therapy Cancer therapies Carcinoma, Pancreatic Ductal Chemotherapy Disparities in care Humans Inequality Lymphatic system Mortality Pancreas Pancreatic adenocarcinoma Pancreatic cancer Pancreatic Neoplasms Patients Race Race factors Racial differences Retrospective Studies Social factors Statistical analysis Survival Survival analysis Therapy Tumors Variance analysis |
Title | Does race affect the long-term survival benefit of systemic therapy in pancreatic adenocarcinoma? |
URI | https://dx.doi.org/10.1016/j.amjsurg.2022.04.004 https://www.ncbi.nlm.nih.gov/pubmed/35430088 https://www.proquest.com/docview/2706709882 https://search.proquest.com/docview/2652028677 |
Volume | 224 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lj9MwELa6y4ULAvEqLMhI3KKUxnET54QqtqueONAiIS6R7dq0ZZugZiv-PjOxnXQXVjwkLlHlpI418_nzjDMzJuQ1M1aqLBMxNymP-UrJuBCcx1pZPhlzpYTCPd35In__SZzP-GwwCEc_9W3_VdPQBrrGzNm_0HbXKTTAb9A5XEHrcP0jvZ_Xpon2EvMAXGFitCwv6-pLjCQcNQfgBnhfpIDk7KaNA3DVnDc6cslYbSYgkISzJ3UkgZpgxdvrTVXv5I1IwGWfmVIdl6FojtKtEXl763Zap-tdHw984Ter5wcZTUcd9r472C3Mxhr8NtbduPwqm7Vc-37k6njLArzdEJPl99FCLs21UM-Wm4vMB7kaR8ciL-JEuKNuAl8zl3TtgZkesW_hKv76hbxwNeF_WiPcdsV2JHdblMUIR9iWu3XnIN8ov73AceGwGGvrwRUn5A4DUkNO_Tz50K364FemwdXCx_tssTe_fNVtdtBtfk5r7yzvk3veUaFTh7AHZGCqh0Qiuiiiizp0UYAM7dBFA7qoRxetLQ3ooh5ddFPRHl30OrrePiIfL2bLd_PYH9IRa5YnVzHLVsoImSidWi5hbudM2TxJtWGa2Uwkxk4kLCpg6ivNxtoaYbVkXGZjpTVP08fktKor85TQsQXjFDglx7J6GMtnRKaFXikLNqpNxJCMgsjKb64WSxmCFLell3GJMi7HvAQZD4kIgi29QekMxRKw8Lu_ngVFlH7yNCXLMautAKd0SF51t4GP8SObrEx9gGeyCXSDVSKH5IlTYDfYdMJTsLnFs38f13Nyt59RZ-T0an8wL8hJszq8bPH4A3Nwu10 |
link.rule.ids | 315,782,786,27933,27934 |
linkProvider | Elsevier |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Does+race+affect+the+long-term+survival+benefit+of+systemic+therapy+in+pancreatic+adenocarcinoma%3F&rft.jtitle=The+American+journal+of+surgery&rft.au=Irfan%2C+Ahmer&rft.au=Fang%2C+Hua+A.&rft.au=Awad%2C+Seifeldin&rft.au=Alkashah%2C+Ahmad&rft.date=2022-09-01&rft.pub=Elsevier+Inc&rft.issn=0002-9610&rft.eissn=1879-1883&rft.volume=224&rft.issue=3&rft.spage=955&rft.epage=958&rft_id=info:doi/10.1016%2Fj.amjsurg.2022.04.004&rft.externalDocID=S0002961022002409 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0002-9610&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0002-9610&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0002-9610&client=summon |