Does race affect the long-term survival benefit of systemic therapy in pancreatic adenocarcinoma?

Systemic therapy is a key management component of pancreatic ductal adenocarcinoma(PDAC). Racial disparities exist in PDAC, often linked to socioeconomic variables. We investigated the impact of race in PDAC patients who had undergone systemic therapy and surgical resection. A retrospective analysis...

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Published in:The American journal of surgery Vol. 224; no. 3; pp. 955 - 958
Main Authors: Irfan, Ahmer, Fang, Hua A., Awad, Seifeldin, Alkashah, Ahmad, Vickers, Selwyn M., Gbolahan, Olumide, Williams, Grant R., Nien-Tsu Wang, Thomas, Dudeja, Vikas, Rose, J. Bart, Reddy, Sushanth
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Language:English
Published: United States Elsevier Inc 01-09-2022
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Abstract Systemic therapy is a key management component of pancreatic ductal adenocarcinoma(PDAC). Racial disparities exist in PDAC, often linked to socioeconomic variables. We investigated the impact of race in PDAC patients who had undergone systemic therapy and surgical resection. A retrospective analysis was performed for all patients who underwent surgical resection for PDAC from 2010 to 2018. 234 patients (78.2% White; 21.8% Black) were included. Black patients presented at a younger age with larger tumors. White patients benefited from systemic therapy with longer overall survival (35vs20 months, p = 0.002). This survival advantage was not present in Black patients (21vs15 months, p = 0.15). Black patients receiving systemic therapy had similar survival as White patients who did not (p = 0.81). Black PDAC patients present at younger ages and with larger initial tumors. In our population, White patients had a longer overall survival after both surgical and systemic therapy. These findings may indicate differences in tumor biology. Further prospective studies are needed. •Pancreatic Cancer is increasingly viewed as a systemic disease, with chemotherapy a key component of treatment.•Known racial disparities exist in the outcomes from pancreatic cancer, often linked to socioeconomic variables.•In patients undergoing surgery and systemic therapy, White patients were found to have improved survival compared to Black.•Differences in tumour biology may account for these differences, but controlled prospective studies are needed.
AbstractList Systemic therapy is a key management component of pancreatic ductal adenocarcinoma(PDAC). Racial disparities exist in PDAC, often linked to socioeconomic variables. We investigated the impact of race in PDAC patients who had undergone systemic therapy and surgical resection. A retrospective analysis was performed for all patients who underwent surgical resection for PDAC from 2010 to 2018. 234 patients (78.2% White; 21.8% Black) were included. Black patients presented at a younger age with larger tumors. White patients benefited from systemic therapy with longer overall survival (35vs20 months, p = 0.002). This survival advantage was not present in Black patients (21vs15 months, p = 0.15). Black patients receiving systemic therapy had similar survival as White patients who did not (p = 0.81). Black PDAC patients present at younger ages and with larger initial tumors. In our population, White patients had a longer overall survival after both surgical and systemic therapy. These findings may indicate differences in tumor biology. Further prospective studies are needed.
BACKGROUNDSystemic therapy is a key management component of pancreatic ductal adenocarcinoma(PDAC). Racial disparities exist in PDAC, often linked to socioeconomic variables. We investigated the impact of race in PDAC patients who had undergone systemic therapy and surgical resection.METHODSA retrospective analysis was performed for all patients who underwent surgical resection for PDAC from 2010 to 2018.RESULTS234 patients (78.2% White; 21.8% Black) were included. Black patients presented at a younger age with larger tumors. White patients benefited from systemic therapy with longer overall survival (35vs20 months, p = 0.002). This survival advantage was not present in Black patients (21vs15 months, p = 0.15). Black patients receiving systemic therapy had similar survival as White patients who did not (p = 0.81).CONCLUSIONBlack PDAC patients present at younger ages and with larger initial tumors. In our population, White patients had a longer overall survival after both surgical and systemic therapy. These findings may indicate differences in tumor biology. Further prospective studies are needed.
Systemic therapy is a key management component of pancreatic ductal adenocarcinoma(PDAC). Racial disparities exist in PDAC, often linked to socioeconomic variables. We investigated the impact of race in PDAC patients who had undergone systemic therapy and surgical resection. A retrospective analysis was performed for all patients who underwent surgical resection for PDAC from 2010 to 2018. 234 patients (78.2% White; 21.8% Black) were included. Black patients presented at a younger age with larger tumors. White patients benefited from systemic therapy with longer overall survival (35vs20 months, p = 0.002). This survival advantage was not present in Black patients (21vs15 months, p = 0.15). Black patients receiving systemic therapy had similar survival as White patients who did not (p = 0.81). Black PDAC patients present at younger ages and with larger initial tumors. In our population, White patients had a longer overall survival after both surgical and systemic therapy. These findings may indicate differences in tumor biology. Further prospective studies are needed. •Pancreatic Cancer is increasingly viewed as a systemic disease, with chemotherapy a key component of treatment.•Known racial disparities exist in the outcomes from pancreatic cancer, often linked to socioeconomic variables.•In patients undergoing surgery and systemic therapy, White patients were found to have improved survival compared to Black.•Differences in tumour biology may account for these differences, but controlled prospective studies are needed.
Author Irfan, Ahmer
Rose, J. Bart
Reddy, Sushanth
Vickers, Selwyn M.
Williams, Grant R.
Fang, Hua A.
Gbolahan, Olumide
Nien-Tsu Wang, Thomas
Awad, Seifeldin
Dudeja, Vikas
Alkashah, Ahmad
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Keywords Pancreatic adenocarcinoma
PDAC
Adjuvant therapy
UAB
Disparities in care
Language English
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Snippet Systemic therapy is a key management component of pancreatic ductal adenocarcinoma(PDAC). Racial disparities exist in PDAC, often linked to socioeconomic...
BackgroundSystemic therapy is a key management component of pancreatic ductal adenocarcinoma(PDAC). Racial disparities exist in PDAC, often linked to...
BACKGROUNDSystemic therapy is a key management component of pancreatic ductal adenocarcinoma(PDAC). Racial disparities exist in PDAC, often linked to...
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SubjectTerms Adenocarcinoma
Adjuvant therapy
Cancer therapies
Carcinoma, Pancreatic Ductal
Chemotherapy
Disparities in care
Humans
Inequality
Lymphatic system
Mortality
Pancreas
Pancreatic adenocarcinoma
Pancreatic cancer
Pancreatic Neoplasms
Patients
Race
Race factors
Racial differences
Retrospective Studies
Social factors
Statistical analysis
Survival
Survival analysis
Therapy
Tumors
Variance analysis
Title Does race affect the long-term survival benefit of systemic therapy in pancreatic adenocarcinoma?
URI https://dx.doi.org/10.1016/j.amjsurg.2022.04.004
https://www.ncbi.nlm.nih.gov/pubmed/35430088
https://www.proquest.com/docview/2706709882
https://search.proquest.com/docview/2652028677
Volume 224
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