The effect of lidocaine/prilocaine cream on an experimental wound healing model

• Published in: European journal of emergency medicine Vol. 8; no. 3; pp. 199 - 201
• Main Authors: Eroglu, E, Eroglu, F, Agalar, F, Altuntas, I, Sutcu, R, Ozbasar, D
• Format: Journal Article
• Language: English
• Published: England Lippincott Williams & Wilkins, Inc 01-09-2001
• Subjects: Administration, Cutaneous; Anesthetics, Local - administration & dosage; Anesthetics, Local - pharmacology; Animals; Drug Combinations; Lidocaine - administration & dosage; Lidocaine - pharmacology; Male; Mice; Mice, Inbred Strains; Models, Animal; Ointments; Prilocaine - administration & dosage; Prilocaine - pharmacology; Random Allocation; Skin - drug effects; Tensile Strength; Wound Healing - drug effects
• ISSN: 0969-9546; 1473-5695
• DOI: 10.1097/00063110-200109000-00007

The effects of lidocaine/prilocaine cream on wound healing were evaluated in this study. An incisional wound model on abdominal wall was performed on mice. A full thickness skin incision 2 cm in length was performed then it was sutured primarily with 4/0 polypropylene. In group I (n  = 10) only suturing was done (control group), in group II (n  = 10) lidocaine cream was applied after suturing on wound site and it was repeated for 6 days (twice in a day), in group III (n  = 10) lidocaine/prilocaine cream was applied topically after suturing and repeated 6 days (twice in a day). At day 7, incisions were excised for evaluating tensile strength and 5-hydroxyproline (5-HP) values. Tensile strength values were lowest in control group and highest in lidocaine/prilocaine treatment group. 5-HP values were also expressed the same results. Both tensile strength and 5-HP values increased significantly in treatment groups in regard to the control (p  < 0.05). It was concluded that lidocaine/prilocaine cream as topical anaesthetic agent had no adverse effect in an incisional wound model, furthermore it may have some beneficial effects on wound healing which remains to be evaluated and it can be used safely in day-to-day emergency practices.