Skin allograft rejection

Skin allograft rejection is a test of the competence of T lymphocytes to mediate in vivo tissue destruction, which in turn reflects their role in critical functions such as anti-viral and tumor immunity. The tail-skin graft procedure described in this unit is useful predominantly because of the ease...

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Bibliographic Details
Published in:	Current protocols in immunology Vol. Chapter 4; p. 4.4.1
Main Authors:	McFarland, Hugh I, Rosenberg, Amy S
Format:	Journal Article
Language:	English
Published:	United States 01-02-2009
Subjects:	Animals Female Graft Rejection - immunology Mice Minor Histocompatibility Antigens - immunology Skin Transplantation - immunology Skin Transplantation - instrumentation Skin Transplantation - methods T-Lymphocytes - immunology Tail Transplantation Immunology Transplantation, Homologous
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Summary:	Skin allograft rejection is a test of the competence of T lymphocytes to mediate in vivo tissue destruction, which in turn reflects their role in critical functions such as anti-viral and tumor immunity. The tail-skin graft procedure described in this unit is useful predominantly because of the ease of preparation and resistance to ischemic (nonspecific) necrosis. Additionally, it is not necessary to sacrifice the donor mouse. However, rejection of tail-skin grafts should not be used to test for genetic homogeneity in breeding experiments or to detect minor histocompatibility (minor-H) antigens because tail skin is less sensitive than trunk skin in detecting such differences.
ISSN:	1934-368X
DOI:	10.1002/0471142735.im0404s84