Multiply resistant Salmonella typhimurium septicaemia in an immunocompromised patient successfully treated with ciprofloxacin

A patient with acute lymphoblastic leukaemia developed a septicaemia due to a multiply resistant strain of Salmonella typhimurium probably contracted in Pakistan. This was associated with splenic abscesses and proved resistant to treatment with a succession of beta-lactam antibiotics--ceftazidime, i...

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Bibliographic Details
Published in:	Journal of antimicrobial chemotherapy Vol. 16; no. 5; p. 667
Main Authors:	Patton, W N, Smith, G M, Leyland, M J, Geddes, A M
Format:	Journal Article
Language:	English
Published:	England 01-11-1985
Subjects:	Adult Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Ciprofloxacin Drug Resistance, Microbial Humans Immunosuppression Leukemia, Lymphoid - drug therapy Male Neutropenia - complications Quinolines - therapeutic use Salmonella Infections - etiology Salmonella typhimurium - drug effects Sepsis - etiology Sepsis - microbiology
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Summary:	A patient with acute lymphoblastic leukaemia developed a septicaemia due to a multiply resistant strain of Salmonella typhimurium probably contracted in Pakistan. This was associated with splenic abscesses and proved resistant to treatment with a succession of beta-lactam antibiotics--ceftazidime, imipenem, and mecillinam despite in-vitro sensitivity. The infection resolved completely with ciprofloxacin therapy--a new 4-quinolone antibiotic which may have an important role in the treatment of systemic salmonella infections.
ISSN:	0305-7453
DOI:	10.1093/jac/16.5.667