The effect of liquid silicone on the corneal endothelium in rabbits: a comparative specular microscopic and histopathologic study

• Published in: Graefe's archive for clinical and experimental ophthalmology Vol. 224; no. 5; pp. 481 - 485
• Main Authors: KAREL, I, FILIPEC, M, VRABEC, F, OBENBERGER, J
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01-01-1986
• Subjects: Animals; Biological and medical sciences; Cell Count; Cornea - drug effects; Cornea - pathology; Endothelium - drug effects; Endothelium - pathology; Medical sciences; Rabbits; Silicones - pharmacology; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the eye and orbit; Cornea; Retinopathy; Rabbit; Exploration; Retina; Lagomorpha; Specular microscopy; Endothelium; Pathology; Vertebrata; Eye disease; Mammalia; Polysiloxane; Experimental surgery; Unsticking; Comparative study
• ISSN: 0721-832X; 1435-702X
• DOI: 10.1007/BF02173369

Specular microscopic and histopathologic findings in the corneal endothelium were compared after the injection of liquid silicone into the anterior chamber of both eyes in 15 rabbits. The findings demonstrated serious damage to the endothelium in the area of contact of liquid silicone with the posterior surface of the cornea and disclosed some problems in the interpretation of specular microscopic findings. An abnormal endothelial mosaic can be probably found even in a zone of preserved intercellular borders or in a zone with a relief of the bases of extinct endothelial cells.