Nematode galectin binds IgE and modulates mast cell activity
Mast cell degranulation is the major mechanism influencing establishment and survival of the abomasal nematode Teladorsagia circumcincta and probably many other gastrointestinal nematodes. Host galectins-3 and -9 have been shown to bind IgE and positively and negatively influence mast cell degranula...
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| Published in: | Veterinary parasitology Vol. 311; p. 109807 |
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| Format: | Journal Article |
| Language: | English |
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01-11-2022
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| Abstract | Mast cell degranulation is the major mechanism influencing establishment and survival of the abomasal nematode Teladorsagia circumcincta and probably many other gastrointestinal nematodes. Host galectins-3 and -9 have been shown to bind IgE and positively and negatively influence mast cell degranulation. As incoming nematodes produce large amounts of galectin, we hypothesised that nematode galectin competes with host galectin and inhibits mast cell degranulation. ELISA was used to show that nematode galectin reduced total IgE activity. Galectin also reduced the binding of sheep IgE to the surface of a mast cell line and decreased the release of LCT-4 and Beta hexosaminidase but not MMP-9. These results indicate that nematode galectin influences mast cell degranulation and identify a potential immunomodulatory mechanism used by nematodes to enhance their establishment and survival.
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•Sheep from a resistant breed had higher IgE anti-galectin activity than susceptible sheep.•Nematode galectin binds IgE and reduces apparent IgE concentrations.•Nematode galectin inhibits mast cell degranulation.•Nematodes produce galectin to enhance their establishment and survival. |
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| AbstractList | Mast cell degranulation is the major mechanism influencing establishment and survival of the abomasal nematode Teladorsagia circumcincta and probably many other gastrointestinal nematodes. Host galectins-3 and -9 have been shown to bind IgE and positively and negatively influence mast cell degranulation. As incoming nematodes produce large amounts of galectin, we hypothesised that nematode galectin competes with host galectin and inhibits mast cell degranulation. ELISA was used to show that nematode galectin reduced total IgE activity. Galectin also reduced the binding of sheep IgE to the surface of a mast cell line and decreased the release of LCT-4 and Beta hexosaminidase but not MMP-9. These results indicate that nematode galectin influences mast cell degranulation and identify a potential immunomodulatory mechanism used by nematodes to enhance their establishment and survival.
[Display omitted]
•Sheep from a resistant breed had higher IgE anti-galectin activity than susceptible sheep.•Nematode galectin binds IgE and reduces apparent IgE concentrations.•Nematode galectin inhibits mast cell degranulation.•Nematodes produce galectin to enhance their establishment and survival. |
| ArticleNumber | 109807 |
| Author | Maruszewska-Cheruiyot, Marta Hernández, Julia N. Krawczak-Wójcik, Katarzyna Donskow-Łysoniewska, Katarzyna Gonzalez, Jorge F. Stear, Michael J. |
| Author_xml | – sequence: 1 givenname: Katarzyna surname: Donskow-Łysoniewska fullname: Donskow-Łysoniewska, Katarzyna email: kdlysoniewska@gmail.com organization: Laboratory of Parasitology, General Karol Kaczkowski Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, Poland – sequence: 2 givenname: Marta surname: Maruszewska-Cheruiyot fullname: Maruszewska-Cheruiyot, Marta organization: Laboratory of Parasitology, General Karol Kaczkowski Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, Poland – sequence: 3 givenname: Katarzyna surname: Krawczak-Wójcik fullname: Krawczak-Wójcik, Katarzyna organization: Laboratory of Parasitology, General Karol Kaczkowski Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, Poland – sequence: 4 givenname: Jorge F. surname: Gonzalez fullname: Gonzalez, Jorge F. organization: Instituto Universitario de Sanidad Animal y Seguridad Alimentaria, Veterinary Faculty, Universidad de Las Palmas de Gran Canaria, Trasmontaña S/N, Arucas, Spain – sequence: 5 givenname: Julia N. surname: Hernández fullname: Hernández, Julia N. organization: Instituto Universitario de Sanidad Animal y Seguridad Alimentaria, Veterinary Faculty, Universidad de Las Palmas de Gran Canaria, Trasmontaña S/N, Arucas, Spain – sequence: 6 givenname: Michael J. surname: Stear fullname: Stear, Michael J. organization: Department of Animal, Plant and Soil Science, Agribio, La Trobe University, Bundoora, VIC 3086, Australia |
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| Keywords | Galectin Degranulation Host-parasite interaction Mast cell IgE Teladorsagia circumcincta |
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