Potential and Capabilities of Porous Silicon as a Material for Intravascular Drug-Eluting Stents: Brief Summary

• Published in: Inorganic materials : applied research Vol. 11; no. 2; pp. 287 - 296
• Main Authors: Kashin, O. A., Krukovskii, K. V., Lotkov, A. I.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 2020; Springer Nature B.V
• Subjects: Biocompatibility; Biodegradability; Chemistry; Chemistry and Materials Science; Continuous coating; Drug carriers; Industrial Chemistry/Chemical Engineering; Inorganic Chemistry; Ion implantation; Magnetron sputtering; Materials Science; Physicochemical Principles of Creating Materials and Technologies; Porous materials; Porous silicon; Silicon; Stents; Submerging; Surgical implants; intravascular drug-eluting stents; porous silicon; drug-containing coating
• ISSN: 2075-1133; 2075-115X
• DOI: 10.1134/S2075113320020161

In search for a drug-containing material when creating polymer-free drug-eluting stents, an analysis of the available literature is carried out. It is shown that one of the promising materials for this purpose is mesoporous silicon (the cross-sectional pore diameter is 2–50 nm), which has high biocompatibility and biodegradability. The main requirements for the porous silicon coating as a drug carrier of metal intravascular stents are formulated. The results of experimental studies are presented, including those performed by the authors, showing the possibility of continuous silicon coating application up to 0.6 μm thick on the stents by magnetron sputtering or plasma-immersion ion implantation and deposition (PIII@D). These methods provide high coating adhesion to the stent material and allow coating both on the external and internal stent surfaces.