Cefiderocol as a Treatment Option for Stenotrophomonas maltophilia Causing Hospital-Acquired/Ventilator-Associated Pneumonia
Multidrug-resistant (MDR) gram-negative bacteria have been causing havoc for the healthcare system because of the rarity of the treatment options available. is a non-fermenting gram-negative bacterium that causes different infections, particularly respiratory tract infections. It displays resistan...
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| Published in: | Curēus (Palo Alto, CA) Vol. 15; no. 5; p. e38613 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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Cureus Inc
05-05-2023
Cureus |
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| Abstract | Multidrug-resistant (MDR) gram-negative bacteria have been causing havoc for the healthcare system because of the rarity of the treatment options available.
is a non-fermenting gram-negative bacterium that causes different infections, particularly respiratory tract infections. It displays resistance to many antibiotics (e.g., carbapenems, fluoroquinolones, and trimethoprim-sulfamethoxazole). Cefiderocol is a novel antibiotic which still in the preclinical stages of Food and Drug Administration (FDA) approval for
. We present the case of a 76-year-old male with end-stage renal disease (ESRD), intubated for acute hypoxemic respiratory failure due to volume overload and worsening oxygenation, who subsequently developed ventilator-associated pneumonia, found to be due to MDR S
The patient ultimately showed clinical improvement with a 7-day course with a renally adjusted dose of cefiderocol. This shows that cefiderocol can prove to be a potential treatment option against serious infections caused by difficult-to-treat |
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| AbstractList | Multidrug-resistant (MDR) gram-negative bacteria have been causing havoc for the healthcare system because of the rarity of the treatment options available.
Stenotrophomonas maltophilia
is a non-fermenting gram-negative bacterium that causes different infections, particularly respiratory tract infections. It displays resistance to many antibiotics (e.g., carbapenems, fluoroquinolones, and trimethoprim-sulfamethoxazole). Cefiderocol is a novel antibiotic which still in the preclinical stages of Food and Drug Administration (FDA) approval for
S. maltophilia
. We present the case of a 76-year-old male with end-stage renal disease (ESRD), intubated for acute hypoxemic respiratory failure due to volume overload and worsening oxygenation, who subsequently developed ventilator-associated pneumonia, found to be due to MDR S
tenotrophomonas maltophilia.
The patient ultimately showed clinical improvement with a 7-day course with a renally adjusted dose of cefiderocol. This shows that cefiderocol can prove to be a potential treatment option against serious infections caused by difficult-to-treat
S. maltophilia. Multidrug-resistant (MDR) gram-negative bacteria have been causing havoc for the healthcare system because of the rarity of the treatment options available. Stenotrophomonas maltophilia is a non-fermenting gram-negative bacterium that causes different infections, particularly respiratory tract infections. It displays resistance to many antibiotics (e.g., carbapenems, fluoroquinolones, and trimethoprim-sulfamethoxazole). Cefiderocol is a novel antibiotic which still in the preclinical stages of Food and Drug Administration (FDA) approval for S. maltophilia. We present the case of a 76-year-old male with end-stage renal disease (ESRD), intubated for acute hypoxemic respiratory failure due to volume overload and worsening oxygenation, who subsequently developed ventilator-associated pneumonia, found to be due to MDR Stenotrophomonas maltophilia. The patient ultimately showed clinical improvement with a 7-day course with a renally adjusted dose of cefiderocol. This shows that cefiderocol can prove to be a potential treatment option against serious infections caused by difficult-to-treat S. maltophilia. Multidrug-resistant (MDR) gram-negative bacteria have been causing havoc for the healthcare system because of the rarity of the treatment options available. is a non-fermenting gram-negative bacterium that causes different infections, particularly respiratory tract infections. It displays resistance to many antibiotics (e.g., carbapenems, fluoroquinolones, and trimethoprim-sulfamethoxazole). Cefiderocol is a novel antibiotic which still in the preclinical stages of Food and Drug Administration (FDA) approval for . We present the case of a 76-year-old male with end-stage renal disease (ESRD), intubated for acute hypoxemic respiratory failure due to volume overload and worsening oxygenation, who subsequently developed ventilator-associated pneumonia, found to be due to MDR S The patient ultimately showed clinical improvement with a 7-day course with a renally adjusted dose of cefiderocol. This shows that cefiderocol can prove to be a potential treatment option against serious infections caused by difficult-to-treat |
| Author | Aziz, Ahmed Ali Mousa, Aliaa Rashid, Muhammad Humayoun Hakobyan, Knkush Bukhari, Syeda Neelam Yamin |
| AuthorAffiliation | 2 Internal Medicine, Nishtar Medical University, Multan, PAK 1 Internal Medicine, Capital Health Regional Medical Center, Trenton, USA |
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| Author_xml | – sequence: 1 givenname: Muhammad Humayoun surname: Rashid fullname: Rashid, Muhammad Humayoun organization: Internal Medicine, Capital Health Regional Medical Center, Trenton, USA – sequence: 2 givenname: Syeda Neelam Yamin surname: Bukhari fullname: Bukhari, Syeda Neelam Yamin organization: Internal Medicine, Nishtar Medical University, Multan, PAK – sequence: 3 givenname: Aliaa surname: Mousa fullname: Mousa, Aliaa organization: Internal Medicine, Capital Health Regional Medical Center, Trenton, USA – sequence: 4 givenname: Ahmed Ali surname: Aziz fullname: Aziz, Ahmed Ali organization: Internal Medicine, Capital Health Regional Medical Center, Trenton, USA – sequence: 5 givenname: Knkush surname: Hakobyan fullname: Hakobyan, Knkush organization: Internal Medicine, Capital Health Regional Medical Center, Trenton, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37284369$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1128/CMR.00019-11 10.1128/AAC.00700-17 10.1016/S1473-3099(20)30731-3 10.1016/j.mib.2017.10.028 10.1016/S1473-3099(20)30796-9 10.1093/cid/ciz827 10.1128/AAC.01436-20 |
| ContentType | Journal Article |
| Copyright | Copyright © 2023, Rashid et al. Copyright © 2023, Rashid et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2023, Rashid et al. 2023 Rashid et al. |
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| DOI | 10.7759/cureus.38613 |
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| Keywords | cefiderocol stenotophomonas maltophilia ventilator-associated pneumonia hospital-acquired pneumonia multi-drug resistant bacteria |
| Language | English |
| License | Copyright © 2023, Rashid et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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| References | Brooke JS (ref3) 2012; 25 Matsumoto S (ref7) 2017; 61 Bassetti M (ref5) 2021; 1 Yamano Y (ref2) 2019; 69 Theuretzbacher U (ref1) 2017; 39 Nakamura R (ref6) 2021; 65 Wunderink RG (ref4) 20211; 21 |
| References_xml | – volume: 25 year: 2012 ident: ref3 article-title: Stenotrophomonas maltophilia: an emerging global opportunistic pathogen publication-title: Clin Microbiol Rev doi: 10.1128/CMR.00019-11 contributor: fullname: Brooke JS – volume: 61 year: 2017 ident: ref7 article-title: Efficacy of cefiderocol against carbapenem-resistant Gram-negative bacilli in immunocompetent-rat respiratory tract infection models recreating human plasma pharmacokinetics publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.00700-17 contributor: fullname: Matsumoto S – volume: 21 year: 20211 ident: ref4 article-title: Cefiderocol versus high-dose, extended-infusion meropenem for the treatment of Gram-negative nosocomial pneumonia (APEKS-NP): a randomised, double-blind, phase 3, non-inferiority trial. The publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(20)30731-3 contributor: fullname: Wunderink RG – volume: 39 year: 2017 ident: ref1 article-title: Global antimicrobial resistance in Gram-negative pathogens and clinical need publication-title: Curr Opin Microbiol doi: 10.1016/j.mib.2017.10.028 contributor: fullname: Theuretzbacher U – volume: 1 year: 2021 ident: ref5 article-title: Efficacy and safety of cefiderocol or best available therapy for the treatment of serious infections caused by carbapenem-resistant Gram-negative bacteria (CREDIBLE-CR): a randomised, open-label, multicentre, pathogen-focused, descriptive, phase 3 trial. The publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(20)30796-9 contributor: fullname: Bassetti M – volume: 69 year: 2019 ident: ref2 article-title: In vitro activity of cefiderocol against a broad range of clinically important Gram-negative bacteria publication-title: Clin Infect Dis doi: 10.1093/cid/ciz827 contributor: fullname: Yamano Y – volume: 65 year: 2021 ident: ref6 article-title: In vitro activity and in vivo efficacy of cefiderocol against Stenotrophomonas maltophilia publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.01436-20 contributor: fullname: Nakamura R |
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| Snippet | Multidrug-resistant (MDR) gram-negative bacteria have been causing havoc for the healthcare system because of the rarity of the treatment options available. ... Multidrug-resistant (MDR) gram-negative bacteria have been causing havoc for the healthcare system because of the rarity of the treatment options available.... |
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| SubjectTerms | Antibiotics Bacteria Bacterial infections Blood Case reports Drug dosages Drug resistance FDA approval Gram-negative bacteria Hemodialysis Hospitalization Hospitals Infectious Disease Internal Medicine Leukocytes Mortality Pathogens Pneumonia Urinary tract diseases Urinary tract infections Urogenital system Ventilators X-rays |
| Title | Cefiderocol as a Treatment Option for Stenotrophomonas maltophilia Causing Hospital-Acquired/Ventilator-Associated Pneumonia |
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