In search of the mechanisms of ketamine's antidepressant effects: How robust is the evidence behind the mTor activation hypothesis [version 1; peer review: 1 approved, 1 approved with reservations]

Extensive evidence on rapid and long-lasting antidepressant effects of intravenous ketamine motivated efforts to identify underlying mechanisms that would enable development of novel drugs with similar efficacy, but improved safety and pharmacokinetic profiles. It has been suggested that the antidep...

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Bibliographic Details

Published in:	F1000 research Vol. 5; p. 634
Main Authors:	Popp, Susanna, Behl, Berthold, Joshi, Jaya Julie, Lanz, Thomas A, Spedding, Michael, Schenker, Esther, Jay, Therese M, Svenningsson, Per, Caudal, Dorian, Cunningham, Jacob I, Deaver, Daniel, Bespalov, Anton
Format:	Journal Article
Language:	English
Published:	2016
Subjects:	Cell Signaling Data Sharing Neuropharmacology & Psychopharmacology Pharmacokinetics & Drug Delivery mTOR data robustness depression ketamine data sharing
Online Access:	Get full text
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