Resuscitation outcomes of infants that do not achieve a 5 min target SpO2 saturation

• Published in: Journal of perinatology Vol. 39; no. 12; pp. 1635 - 1639
• Main Authors: Katheria, Anup C., Hassen, Kasim, Rich, Wade, Poeltler, Debra, Finer, Neil
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01-12-2019; Nature Publishing Group
• Subjects: 692/308/174; 692/308/409; Babies; Birth weight; Brain damage; Gestational age; Heart rate; Hypoxia; Infants; Medicine; Medicine & Public Health; Morbidity; Newborn babies; Oxygen; Oxygen content; Oxygen saturation; Pediatric Surgery; Pediatrics; Pressure; Pulse oximetry; Respiratory tract; Resuscitation; Variables
• ISSN: 0743-8346; 1476-5543
• DOI: 10.1038/s41372-019-0491-x

Objective
To determine differences in the duration and level of resuscitation between infants that achieve a peripheral oxygen saturation (SpO
2
) of 80% by 5 min compared with those who remain below 80% saturation.
Study design
Infants < 32 weeks GA were analyzed. Pulse rate, SpO
2
, airway pressure, and fraction of inspired oxygen were collected during the first 10 min of life.
Results
Two hundred and eighty-four infants were analyzed of which 100 had SpO
2
 < 80% at 5 min of life. Composite outcome of death and any IVH was greater in the <80% at 5 min group. These infants had lower heart rates and lower SpO
2
despite increased mean airway pressure and higher FiO
2
(
p
 < 0.001).
Conclusion
Infants <32 weeks GA that do not achieve a peripheral arterial saturation of 80% by 5 min of life experience more death or severe IVH. This association is amongst the strongest seen of any predictor of morbidity in the delivery room.